Tetrahedron Letters p. 2257 - 2260 (1982)
Update date:2022-08-04
Topics:
Gaffney, B. L.
Jones, R. A.
The protection of the 6-oxo group of deoxyguanosine with the 2-trimethylsilylethyl (2), phenylthioethyl (3), 4-nitrophenylthioethyl (4), 4-nitrophenethyl (5), and cyanoethyl (6) groups is described.Each protecting group is introduced in good yield and is cleaved under mild conditions.Compatibility with the various approaches to oligonucleotide synthesis is discussed.
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