A NEW STRATEGY FOR THE PROTECTION OF DEOXYGUANOSINE DURING OLIGONUCLEOTIDE SYNTHESIS

DOI: 10.1016/S0040-4039(00)87315-3

Source and publish data:

Tetrahedron Letters p. 2257 - 2260 (1982)

Update date:2022-08-04

Topics:

Authors:

Gaffney, B. L.

Jones, R. A.

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Article abstract of DOI:10.1016/S0040-4039(00)87315-3

The protection of the 6-oxo group of deoxyguanosine with the 2-trimethylsilylethyl (2), phenylthioethyl (3), 4-nitrophenylthioethyl (4), 4-nitrophenethyl (5), and cyanoethyl (6) groups is described.Each protecting group is introduced in good yield and is cleaved under mild conditions.Compatibility with the various approaches to oligonucleotide synthesis is discussed.

Full text of DOI:10.1016/S0040-4039(00)87315-3

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