Modification of DNA with Potent Mutacarcinogenic 2-Amino-6-methyldipyridoimidazole Isolated from a Glutamic Acid Pyrolysate: Structure of the Modified Nucleic Acid Base and Initial Chemical Event Caused by the Mutagen

Article abstract of DOI:10.1021/ja00390a040

2-Amino-6-methyldipyrido<1,2-a:3',2'-d>imidazole (Glu-P-1), a potent mutacarcinogen isolated from a glutamic acid pyrolysate, reacted with DNA in vitro and in vivo.The structure of the modified nucleic acid base was determined as 2-(8-guanylylamino)-6-met