Modification of DNA with Potent Mutacarcinogenic 2-Amino-6-methyldipyridoimidazole Isolated from a Glutamic Acid Pyrolysate: Structure of the Modified Nucleic Acid Base and Initial Chemical Event Caused by the Mutagen

DOI: 10.1021/ja00390a040

Source and publish data:

Journal of the American Chemical Society p. 7636 - 7640 (1982)

Update date:2022-08-04

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Authors:

Hashimoto, Yuichi

Shudo, Koichi

Okamoto, Toshihiko

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Article abstract of DOI:10.1021/ja00390a040

2-Amino-6-methyldipyrido<1,2-a:3',2'-d>imidazole (Glu-P-1), a potent mutacarcinogen isolated from a glutamic acid pyrolysate, reacted with DNA in vitro and in vivo.The structure of the modified nucleic acid base was determined as 2-(8-guanylylamino)-6-met

Full text of DOI:10.1021/ja00390a040

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