AMINO ACID DERIVATIVES THAT STABILIZE SECONDARY STRUCTURES OF POLYPEPTIDES. I. SYNTHESIS OF LL-3-AMINO-2-PIPERIDONE-6-CARBOXYLIC ACID (LL-Acp), A NOVEL BETA-TURN-FORMING AMINO ACID

Article abstract of DOI:10.1016/S0040-4039(00)87699-6

A six-step synthesis is reported of LL-3-amino-2-piperidone-6-carboxylic acid from L-homoserine lactone and the mono-t-butyl ester of N-benzyloxycarbonylaminomalonic acid.Evidence of chiral integrity is discussed.