CAS No.71-58-9,Medroxyprogesterone 17-acetate Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	71-58-9
Name:	Medroxyprogesterone 17-acetate
Article Data:	32

Formula:	C₂₄H₃₄O₄
Molecular Weight:	386.532
Synonyms:	Pregn-4-ene-3,20-dione,17-hydroxy-6a-methyl-, acetate(7CI,8CI);Progesterone, 17-hydroxy-6a-methyl-, acetate (6CI);17a-Acetoxy-6a-methylprogesterone;17a-Hydroxy-6a-methyl-4-pregnene-3,20-dione17-acetate;17a-Hydroxy-6a-methylprogesteroneacetate;6a-Methyl-17-acetoxyprogesterone;6a-Methyl-17a-acetoxy-D4-pregnene-3,20-dione;6a-Methyl-17a-acetoxypregn-4-ene-3,20-dione;Amen;CBP 1011;Clinovir;Colirest;Curretab;Cycrin;DMPA;Depo-Prodasone;Depo-Ralovera;Depo-promone;Depomedroxyprogesterone acetate;Farlutal;Farlutin;Lutoral;Medroprogesterone acetate;
EINECS:	200-757-9
Density:	1.13 g/cm³
Melting Point:	206-207 °C(lit.)
Boiling Point:	496.4 °C at 760 mmHg
Flash Point:	213.2 °C
Solubility:	<0.1 g/100 mL at 23 °C in water
Appearance:	white crystalline powder
Hazard Symbols:	Xn
Risk Codes:	40-48
Safety:	22-36/37/39-45
PSA:	60.44000
LogP:	4.51270

Synthetic route

: 32634-95-0
17α-Acetoxy-6-methylene-pregn-4-ene-3,20-dione

: 71-58-9
Medroxyprogesterone acetate

Conditions

Conditions	Yield
With ethanol; 5%-palladium/activated carbon In cyclohexene at 75 - 78℃; for 5h; Reagent/catalyst; Temperature;	87.5%
With sodium acetate; cyclohexene; palladium on activated charcoal In ethanol; water Heating / reflux;

: 809-01-8
3-cycloethylenedioxy-6-methyl-17α-acetoxy-pregn-5-ene-20-one

: 71-58-9
Medroxyprogesterone acetate

Conditions

Conditions	Yield
With silica gel; copper(II) sulfate In chloroform for 2h; Heating;	81%

: 2381-48-8
6-methylpregn-5-ene-3β,17α-diol-20-one 17-acetate

: 71-58-9
Medroxyprogesterone acetate

Conditions

Conditions	Yield
With cyclohexanone; aluminum isopropoxide; toluene
With aluminum isopropoxide

: 986-96-9
3,17-diacetoxy-6-methyl-pregna-3,5-dien-20-one

: 71-58-9
Medroxyprogesterone acetate

Conditions

Conditions	Yield
With hydrogenchloride

: 520-85-4
Medroxyprogesterone

: 108-24-7
acetic anhydride

: 71-58-9
Medroxyprogesterone acetate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; acetic acid

: 6-Formil-3-(2'-chloro-etossi)-Δ3,5-pregnadien-17α-ol-20-one acetato

: 71-58-9
Medroxyprogesterone acetate

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In methanol

: 1863-39-4
3β-acetoxy-17α-hydroxy-5-pregnen-20-one

: 71-58-9
Medroxyprogesterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: benzene; toluene-4-sulfonic acid 2: peroxybenzoic acid; chloroform 3: benzene; diethyl ether 4: aqueous methanol.H2SO4 5: CrO3; pyridine 6: aqueous HCl 7: acetic acid; toluene-4-sulfonic acid View Scheme

: 113665-92-2
3β,5,17-trihydroxy-6β-methyl-5α-pregnan-20-one

: 71-58-9
Medroxyprogesterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: CrO3; pyridine 2: aqueous HCl 3: acetic acid; toluene-4-sulfonic acid View Scheme

: 23706-51-6
5,17-dihydroxy-6β-methyl-5α-pregnane-3,20-dione

: 71-58-9
Medroxyprogesterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous HCl 2: acetic acid; toluene-4-sulfonic acid View Scheme
Multi-step reaction with 2 steps 1: HCl; CHCl3 2: acetic acid; toluene-4-sulfonic acid View Scheme
Multi-step reaction with 3 steps 1: pyridine; aq. NaOH solution 2: HCl; CHCl3 3: acetic acid; toluene-4-sulfonic acid View Scheme

: 19699-76-4
20,20-ethanediyldioxy-6β-methyl-5α-pregnane-3β,5,17-triol

: 71-58-9
Medroxyprogesterone acetate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: aqueous methanol.H2SO4 2: CrO3; pyridine 3: aqueous HCl 4: acetic acid; toluene-4-sulfonic acid View Scheme

Raw Materials

986-96-9

1863-39-4

108-24-7

520-85-4

809-01-8

Downstream Products

520-85-4

595-33-5

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Chemistry

The Molecular Structure of Medroxyprogesterone Acetate (CAS NO.71-58-9):

Empirical Formula: C₂₄H₃₄O₄
Molecular Weight: 386.5244
Appearance: white crystalline powder
Nominal Mass: 386
Average Mass: 386.5244
Monoisotopic Mass: 386.24571
Index of Refraction: 1.538
Molar Refractivity: 106.71 cm³
Molar Volume: 340.8 cm³
Surface Tension: 43.2 dyne/cm
Density: 1.13 g/cm³
Flash Point: 213.2 °C
Enthalpy of Vaporization: 76.41 kJ/mol
Boiling Point: 496.4 °C at 760 mmHg
Vapour Pressure: 5.44E-10 mmHg at 25 °C
Water Solubility: <0.1 g/100 mL at 23 °C
Melting Point: 206-207 °C
Stability: Stable, but weakly air and light sensitive. Incompatible with strong oxidizing agents
Classification Code: Antineoplastic Agents; Antineoplastic agents, hormonal; Contraceptive Agents; Contraceptive agents, female; Contraceptive agents, male; Drug / Therapeutic Agent; Hormone; Human Data; Mutation data; Progestin; Reproductive Control Agents; Reproductive Effect; Tumor data
IUPAC Name: [(6S,8R,9S,10R,13S,14S,17R)-17-Acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
Synonyms: (6-Alpha)-17-(acetyloxy)-6-methylpreg-4-ene-3,20-dione ; 17-(Acetyloxy)-6-methyl-(6-alpha)-pregn-4-ene-20-dione ; 17-(Acetyloxy)-6-methyl-20-dion(6alpha)-pregn-4-ene- ; 17-Acetoxy-6-alpha-methylprogesterone ; 17-Alpha-hydroxy-6-alpha-methylpregn-4-ene-3,20-dioneacetate ; 17-Alpha-hydroxy-6-alpha-methyl-progesteronacetate ; 17-Alpha-hydroxy-6-alpha-methylprogesteroneacetate ; 17-Hydroxy-6-alpha-methylpregn-4-ene-3,20-dioneacetate

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 5gm/kg (5000mg/kg)		Drugs in Japan Vol. -, Pg. 1196, 1990.
mouse	LD50	intraperitoneal	> 1500mg/kg (1500mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 6135, 1984.
mouse	LD50	oral	> 16gm/kg (16000mg/kg)	ENDOCRINE: ADRENAL CORTEX HYPOPLASIA	Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 6135, 1984.
mouse	LD50	subcutaneous	> 1500mg/kg (1500mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 6135, 1984.
rat	LD50	intraperitoneal	> 900mg/kg (900mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 6135, 1984.
rat	LD50	oral	> 6400mg/kg (6400mg/kg)	LIVER: OTHER CHANGES	Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 6135, 1984.
rat	LD50	subcutaneous	> 900mg/kg (900mg/kg)		Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 6135, 1984.
women	TDLo	intravenous	10mg/kg (10mg/kg)	SENSE ORGANS AND SPECIAL SENSES: INCREASED INTRAOCULAR PRESSURE: EYE	Advances in Planned Parenthood. Vol. 8, Pg. 103, 1972.
women	TDLo	intravenous	21mg/kg (21mg/kg)	SENSE ORGANS AND SPECIAL SENSES: INCREASED INTRAOCULAR PRESSURE: EYE	Advances in Planned Parenthood. Vol. 8, Pg. 103, 1972.

Safety Profile

Hazard Codes: Harmful Xn
Risk Statements: 40-48
R40: Limited evidence of a carcinogenic effect
R48: Danger of serious damage to health by prolonged exposur
Safety Statements: 22-36/37/39-45
S22: Do not breathe dust
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection

S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: TU5010000

Specification

Incompatibilities: Flammable and/or toxic gases are generated by combination with with alkali metals, nitrides, and strong reducing agents Reacts with oxoacids and carboxylic acids to form esters plus water Incompatible with oxidizing agents.