Chemical and Pharmaceutical Bulletin p. 3183 - 3188 (1991)
Update date:2022-08-04
Topics: Synthesis Derivatives Antitumor Activity
Sawada
Matsuoka
Nokata
Nagata
Furuta
Yokokura
Miyasaka
20(S)-Camptothecin derivatives having nitro, amino, chloro, bromo, hydroxyl and methoxyl groups in the A-ring were synthesized. B-Ring hydrogenated camptothecin (2a) was converted into 10-hydroxycamptothecin (6e) by treatment with lead tetraacetate in trifluoroacetic acid. 10-Substituted derivatives (6) were obtained by a photoreaction of N-oxides (9). The cytotoxicity of the A-ring modified camptothecins was evaluated against KB cells in vitro and leukemia L1210 in mice. 7-Ethyl-10-hydroxycamptothecin (6i) was identified as a potential derivative for further modification.
View MoreYangling Ciyuan biotech Co., Ltd.
Contact:86-15802970736
Address:2-1804, International Park Mansion, No.2, South Fengdeng Road, Lianhu District
Contact:+86-871-65217109
Address:132 Lanhei Road, Kunming Institute of Botany, Chinese Academy of Sciences
Contact:+8618766299236
Address:ROOM808, BUILDING2,NO.230 SHEN ZHEN ROAD, LAOSHAN DISTRICT
website:http://www.tbbmed.com
Contact:86--21-50498136
Address:Room 6002, Building 7-1, No.160 Basheng Road,Pudong Area,Shanghai China
Weifang Ocean Trading Co., Ltd.
Contact:+86-536-2081155
Address:Room2606, Yuqing Building, 518#, Yuquan Road, High-tech Development Zone, Weifang City, Shandong Province, China
Doi:10.1021/cm3032994
(2013)Doi:10.1016/j.jorganchem.2005.06.016
(2005)Doi:10.1002/asia.201700867
(2017)Doi:10.1039/c39860001364
(1986)Doi:10.1081/NCN-200059241
(2005)Doi:10.1055/s-1983-30342
(1983)
