The improved synthesis of enantiopure (s)-N-arylmethyl-5-oxoprolines

Article abstract of DOI:10.1080/00397919808004908

A mild procedure for the preparation of enantiopure N-alkylated (S)- (+)-5-oxoprolines 3a-r is described. The method starting from (S)-glutamic acid appears generally applicable to substrates with a wide range of substituents.

Full text of DOI:10.1080/00397919808004908

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The Improved Synthesis
of Enantiopure (S)-N-
Arylmethyl-5-Oxoprolines
Stefan Marchalin a , Katarina Kadlecikova a ,
Nathalie Bar b & Bernard Decroix b
a Department of Organic Chemistry, Slovak
Technical University, Radlinského 9, 81237,
Bratislava, Slovak republic E-mail:
b Laboratoire de Chimie, Faculté des Sciences
et Techniques de l'Université du Havre, 30 rue
Gabriel Péri, 76600, Le Havre, France
Published online: 22 Aug 2006.
To cite this article: Stefan Marchalin , Katarina Kadlecikova , Nathalie Bar &
Bernard Decroix (1998) The Improved Synthesis of Enantiopure (S)-N-Arylmethyl-5-
Oxoprolines, Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 28:19, 3619-3624, DOI:
10.1080/00397919808004908
To link to this article: http://dx.doi.org/10.1080/00397919808004908
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