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| CAS No.: | 501-30-4 |
|---|---|
| Name: | Kojic acid |
| Article Data: | 18 |
| Cas Database | |
| Molecular Structure: | |
|
|
|
| Formula: | C6H6O4 |
| Molecular Weight: | 142.111 |
| Synonyms: | Kojic acid(whitening agent in cosmetic);3-O-Ethyl ascorbic acid;5-Hydroxy-2-hydroxymethyl-4H-4-pyranone;4H-Pyran-4-one,5-hydroxy-2-(hydroxymethyl)-;5-Hydroxy-2-hydroxymethyl-4-pyrone;5-Hydroxy-2-(hydroxymethyl)-4-pyrone;5-18-02-00516 (Beilstein Handbook Reference);5-hydroxy-2-(hydroxymethyl)pyran-4-one;5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one;2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one;4H-Pyran-4-one, 5-hydroxy-2- (hydroxymethyl)-; |
| EINECS: | 207-922-4 |
| Density: | 1.542 g/cm3 |
| Melting Point: | 152-155 °C |
| Boiling Point: | 401.7 °C at 760 mmHg |
| Flash Point: | 179.9 °C |
| Solubility: | Soluble in water |
| Appearance: | Tan powder |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 40-68 |
| Safety: | 22-24/25-36/37-36 |
| Transport Information: | N/A |
| PSA: | 70.67000 |
| LogP: | -0.16230 |
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- 26209-93-8
5-acetoxy-2-acetoxymethyl-4H-pyran-4-one
- 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
| Conditions | Yield |
|---|---|
| With sodium methylate In methanol for 1h; | 95% |
| With methanol; ammonia |
- 7559-81-1
chlorokojic acid
- 67-64-1
acetone
A
- 644-46-2
allomaltol
B
- 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
C
- 16065-34-2
iodokojic acid
D
- 3019-04-3
iodoacetone
| Conditions | Yield |
|---|---|
| With sodium iodide at 45℃; for 24h; Substitution; | A n/a B n/a C 78% D n/a |
- 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
| Conditions | Yield |
|---|---|
| With silica gel In methanol at 60℃; for 3h; Inert atmosphere; | 70% |
- 501-30-4
5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
| Conditions | Yield |
|---|---|
| Stage #1: 2-keto-D-glucose With sodium acetate; acetic anhydride In N,N-dimethyl-formamide for 23h; Stage #2: With sodium methylate In methanol for 1h; | 20% |
| Conditions | Yield |
|---|---|
| With Aspergillus oryzae Bei der Vergaerung; |
| Conditions | Yield |
|---|---|
| bei der Einw.verschiedener Essigbakterien; |
| Conditions | Yield |
|---|---|
| durch Aspergillus oryzae; |
| Conditions | Yield |
|---|---|
| bei der Einw.von Aspergillus oryzae; |
| Conditions | Yield |
|---|---|
| With Aspergillus oryzae Bei der Vergaerung; |
| Conditions | Yield |
|---|---|
| With aspergillus glaucus Bei der Vergaerung; | |
| bei der Einw.von Aspergillus glaucus; |
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Chemistry
Molecular Formula: C6H6O4
Molecular Weight: 142.11
EINECS: 207-922-4
Index of Refraction: 1.606
Density: 1.542 g/cm3
Flash Point: 179.9 °C
Enthalpy of Vaporization: 75.44 kJ/mol
Boiling Point: 401.7 °C at 760 mmHg
Vapour Pressure: 4.01E-08 mmHg at 25 °C
Melting point: 152-155 °C
Water solubility: Soluble
Appearance: Tan powder
Structure of Kojic acid (CAS NO.501-30-4):
IUPAC Name: 5-Hydroxy-2-(hydroxymethyl)pyran-4-one
Product Category of Kojic acid (CAS NO.501-30-4): Heterocycles;Plant Oils, Toxins, Phenolic Acids & Derivatives
Uses
Kojic acid (CAS NO.501-30-4) can be used in food and cosmetics to preserve or change colors of substances. On cut fruits it is used to prevent oxidative browning, in seafood to preserve pink and red colors, and in cosmetics to lighten skin.
Toxicity Data With Reference
| 1. | mmo-sat 1 mg/plate | MUREAV Mutation Research. 67 (1979),367. | ||
| 2. | mma-sat 4 mg/plate | JTSCDR Journal of Toxicological Sciences. 7 (1982),255. | ||
| 3. | ivn-rat LDLo:1000 mg/kg | 85ERAY Antibiotics: Origin, Nature, and Properties. 3 (1978),1755. | ||
| 4. | orl-mus LDLo:4 g/kg | NATUAS Nature. 155 (1945),302. | ||
| 5. | ipr-mus LD50:250 mg/kg | 85GDA2 CRC Handbook of Antibiotic Compounds, Volumes 1-9. 5 (1981),393. | ||
| 6. | scu-mus LDLo:1500 mg/kg | NATUAS Nature. 155 (1945),302. | ||
| 7. | ivn-mus LDLo:1500 mg/kg | NATUAS Nature. 155 (1945),302. | ||
| 8. | ivn-dog LDLo:1000 mg/kg | 85ERAY Antibiotics: Origin, Nature, and Properties. 3 (1978),1755. | ||
| 9. | ivn-rbt LDLo:1000 mg/kg | 85ERAY Antibiotics: Origin, Nature, and Properties. 3 (1978),1755. |
Consensus Reports
EPA Genetic Toxicology Program.
Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion, intravenous, and subcutaneous routes. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes.
Hazard Codes: 
Xn
Risk Statements:
R40:Limited evidence of a carcinogenic effect
R68 :Possible risk of irreversible effects
Safety Statements:
S22:Do not breathe dust
S24/25:Avoid contact with skin and eyes
S36/37:Wear suitable protective clothing and gloves
S36 :Wear suitable protective clothing
WGK Germany: 3
Specification
Kojic acid , its cas register number is 501-30-4. It also can be called 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one ; and 5-Hydroxy-2-hydroxymethyl-4-pyrone . It is a mild inhibitor of the formation of pigment in plant and animal tissues. It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.
In addition, Kojic acid (CAS NO.501-30-4) is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide.