CAS No.38304-91-5,Minoxidil Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	38304-91-5
Name:	Minoxidil
Article Data:	19
Cas Database

Formula:	C₉H₁₅N₅O
Molecular Weight:	209.251
Synonyms:	Mimosine;Minoxidil(USP 24);Minoxidil USP/BP;Loniten (TN);U-10,858;2,4-Diamino-6-piperidinopyrimidine 3-N-oxide;Prexidil;6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine;Alopexil;U 10858;Regaine;Minossidile [Italian];Prestwick_521;Minoximen;2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide;Loniten;2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine;Minoxidilum [INN-Latin];Pyrimidine, 2,4-diamino-6-piperidino-, 3-oxide;Minoxidil (USP);PDP;Tricoxidil;6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide;2,6-Diamino-4-piperidinopyrimidin-1-oxid;Rogaine;Alostil;3-hydroxy-2-imino-6-(1-piperidyl)pyrimidin-4-amine;6-Piperidino-2,4-diaminopyrimidine 3-oxide;2,4-Pyrimidinediamine,6-(1-piperidinyl)-,3- oxide;2,4-Diamino-6-piperidinopyrimidine 3-oxide;2,4-Diamino-6-piperidinilpirimidina-3-ossido [Italian];Theroxidil;4-Pyrimidinamine, 2,3-dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-;
EINECS:	253-874-2
Density:	1.52 g/cm³
Melting Point:	272-274 °C (dec.)(lit.)
Boiling Point:	351.7 °C at 760 mmHg
Flash Point:	166.5 °C
Solubility:	Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol.
Appearance:	White crystalline powder
Hazard Symbols:	Xn, T+
Risk Codes:	22-36/37/38-26/27/28
Safety:	26-36-45-36/37/39-22
PSA:	91.16000
LogP:	0.91830

Synthetic route

: 35139-67-4
2,6-diamino-4-chloro-pyrimidine N-oxide

: 38304-91-5
2,4-diamino-6-piperidinopyrimidine 3-oxide

Conditions

Conditions	Yield
at 106℃; for 2h;	80%

: 110-89-4
piperidine

: 35139-67-4
2,6-diamino-4-chloro-pyrimidine N-oxide

: 38304-91-5
2,4-diamino-6-piperidinopyrimidine 3-oxide

Conditions

Conditions	Yield
In dimethyl sulfoxide at 80℃; Rate constant; Thermodynamic data; various temp.; ΔH, ΔS;

: 65277-42-1
ketoconazole

: 38304-91-5
2,4-diamino-6-piperidinopyrimidine 3-oxide

Raw Materials

110-89-4

65277-42-1

35139-67-4

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Specification

1. Introduction of Minoxidil
Minoxidil is one kind of white crystalline powder. The IUPAC Name of this chemical is 3-Hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine. Besides, the Product Category of Minoxidil is Intermediates & Fine Chemicals;Pharmaceuticals;API's;Potassium channel. In addition, its Classification Code is Antihypertensive; Antihypertensive agents; Cardiovascular Agents; Drug / Therapeutic Agent; Hair growth stimulant [topical]; Human Data; Reproductive Effect; Vasodilator agents. What's more, Minoxidil has poor solubility in water but soluble in alcohol and propylene glycol; sparingly soluble in methanol; slightly soluble in water; practically insoluble in chloroform, acetone and ethyl acetate.

In 2007 a new foam-based formulation of 5% minoxidil was shown to be as effective as the liquid-based treatment for male pattern baldness.

2. Properties of Minoxidil
Physical properties about Minoxidil are:
(1)Index of Refraction: 1.723; (2)Density: 1.52 g/cm³; (3)Flash Point: 166.5 °C; (4)Melting point: 272-274 °C (dec.)(lit.); (5)Appearance: white crystalline solid; (6)Enthalpy of Vaporization: 69.06 kJ/mol; (7)Boiling Point: 351.7 °C at 760 mmHg; (8)Vapour Pressure: 2.38E-06 mmHg at 25 °C; (9)XLogP3: 1.2; (10)H-Bond Donor: 3; (11)H-Bond Acceptor: 3.

3. Structure Descriptors of Minoxidil
(1)InChI: InChI=1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
(2)InChIKey: ZIMGGGWCDYVHOY-UHFFFAOYSA-N
(3)Canonical SMILES: C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O
(4)Smiles: c1(N2CCCCC2)cc(n(=O)c(n1)N)N

4. Toxicity of Minoxidil

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	LDLo	oral	69mg/kg/34W-I (69mg/kg)	CARDIAC: PERICARDITIS CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)	Western Journal of Medicine. Vol. 143, Pg. 527, 1985.
man	TDLo	oral	107ug/kg/3D-I (0.107mg/kg)	BLOOD: THROMBOCYTOPENIA	Annals of Internal Medicine. Vol. 92, Pg. 874, 1980.
mouse	LD50	intraperitoneal	560mg/kg (560mg/kg)		Bollettino Chimico Farmaceutico. Vol. 121, Pg. 16, 1982.
mouse	LD50	intravenous	51mg/kg (51mg/kg)		Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977.
mouse	LD50	oral	> 1gm/kg (1000mg/kg)		Bollettino Chimico Farmaceutico. Vol. 121, Pg. 16, 1982.
rat	LD50	intraperitoneal	759mg/kg (759mg/kg)		Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977.
rat	LD50	intravenous	49mg/kg (49mg/kg)		Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977.
rat	LD50	oral	1321mg/kg (1321mg/kg)		Toxicology and Applied Pharmacology. Vol. 39, Pg. 1, 1977.
women	TDLo	oral	200ug/kg (0.2mg/kg)	VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION GASTROINTESTINAL: NAUSEA OR VOMITING	Archives of Internal Medicine. Vol. 146, Pg. 2075, 1986.

5. Safety information of Minoxidil
Hazard Codes: Harmful

Xn,

T+
Risk Statements: 22-36/37/38-26/27/28
R22:Harmful if swallowed.
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-45-36/37/39-22
S22:Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

6. Uses of Minoxidil
Minoxidil (CAS NO.38304-91-5) can slow or stop hair loss and promote hair regrowth, so it is used for treatment of androgenic alopecia, among other baldness treatments. It was first used by to treat high blood pressure. Now off-patent, it is available over-the-counter for the treatment of androgenic alopecia. Minoxidil was first used exclusively as an oral drug to treat high blood pressure.

7. Production of Minoxidil
Minoxidil can be got from cyclization by methyl cyanoacetate chloride, to give 4-chloro-2,6-diaminopyrimidine (See 08910), perbenzoic acid and then with an oxidation reaction to obtain 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-chloropyrimidine (C4H5CIN4O), the last condensation and Hexahydropyridine obtained Minoxidil.

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