Journal of Medicinal Chemistry p. 239 - 244 (1984)
Update date:2022-08-05
Topics:
Jarvis, Bruce B.
Midiwo, Jacob O.
Mazzola, Eugene P.
Various 8β-hydroxy, 16-hydroxy, and 9β,10β-epoxy derivatives of roridins A and H and verrucarins A and J have been prepared and tested in vivo against P388 mouse leukemia.The 9β,10β-epoxy derivatives and 16-hydroxy derivatives consistently exhibit very high activity.The 8β-hydroxy-9β,10β-epoxy and 16-hydroxy-9β,10β-epoxy derivatives of verrucarin A and roridin A exhibit extraordinary activity against P388.The 8β-hydroxy-9β,10β-epoxy and 16-hydroxy-9β,10β-epoxy derivatives of verrucarin A and roridin A exhibit extraordinary activity against P388.
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