Bioorganic and Medicinal Chemistry Letters p. 2793 - 2798 (2008)
Update date:2022-07-31
Topics:
Claridge, Stephen
Raeppel, Franck
Granger, Marie-Claude
Bernstein, Naomy
Saavedra, Oscar
Zhan, Lijie
Llewellyn, David
Wahhab, Amal
Deziel, Robert
Rahil, Jubrail
Beaulieu, Normand
Nguyen, Hannah
Dupont, Isabelle
Barsalou, Annie
Beaulieu, Carole
Chute, Ian
Gravel, Serge
Robert, Marie-France
Lefebvre, Sylvain
Dubay, Marja
Pascal, Roussen
Gillespie, Jeff
Jin, Zhiyun
Wang, James
Besterman, Jeffrey M.
MacLeod, A. Robert
Vaisburg, Arkadii
A series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases is described. The compounds demonstrated potency with IC50 values in the low nanomolar range in vitro while the lead compound also showed in vivo activity against various human tumor xenograft models in mice. Further exploration of this class of compounds is underway.
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