N′,2-Diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists

DOI: 10.1016/j.bmcl.2006.08.086

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 5748 - 5751 (2006)

Update date:2022-08-03

Topics:

Authors:

Elliott, Jason M.

Carling, Robert W.

Chambers, Mark

Chicchi, Gary G.

Hutson, Peter H.

Jones, A. Brian

MacLeod, Angus

Marwood, Rose

Meneses-Lorente, Georgina

Mezzogori, Elena

Murray, Fraser

Rigby, Michael

Royo, Inmaculada

Russell, Michael G.N.

Sohal, Bindi

Tsao, Kwei Lan

Williams, Brian

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Article abstract of DOI:10.1016/j.bmcl.2006.08.086

A new class of potent NK₃R antagonists based on the N′,2-diphenylquinoline-4-carbohydrazide core is described. In an ex vivo assay in gerbil, the lead compound 2g occupies receptors within the CNS following oral dosing (Occ₉₀ 30 mg/k

Full text of DOI:10.1016/j.bmcl.2006.08.086

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