1273-94-5

Upstream product

• 108-30-5 succinic acid anhydride 
• 102-54-5 ferrocene 
• 75-36-5 acetyl chloride 
• 79-37-8 oxalyl dichloride 
• 156670-90-5 acetylferrocene-d4.82 
• 12291-11-1 1,1'-bis(tri-n-butylstannyl)ferrocene 
• 1273-76-3 iodoferrocene 
• 108-24-7 acetic anhydride 

Downstream Products

• 1273-97-8 1,1'-diethylferrocene 
• 402572-04-7 1-acetyl-1'-cinnamoylferrocene 
• 37684-88-1 1,1'-dicinnamoylferrocene 
• 56370-58-2 1-acetyl-1'-(p-chlorocinnamoyl)ferrocene 
• 40470-49-3 1,1'-bis[(p-chlorocinnamoyl)]ferrocene 
• 32629-33-7 N',N''-(1,1'-ferrocenylbis(ethan-1-ylidene))bis(4-methylbenzenesulfonohydrazide) 
• 402572-17-2 1-acetyl-1'-(β-phenylvinyl)acryloylferrocene 
• 402572-12-7 1,1'-bis(β-phenylvinyl)acryloylferrocene 
• 252961-93-6 ((C₅H₄COCH₂)2CHC₆H₄(NC₁₀H₂₀O₄))Fe 
• 182273-76-3 [Fe((η5-C5H4)-C(CH3)=N-C6H4Cl-4)2] 
• 900178-89-4 Fe(C₅H₄CO(CHCH)2C₆H₄N(CH₃)2)2 
• 252961-90-3 [Fe(C₅H₄COCHCHC₆H₄N(C₂H₅)2)2] 
• 252961-91-4 [Fe(C₅H₄COCHCHC₆H₄NO₄(CH₂)10)2] 
• 1013035-33-0 1,1'-diacetylferricenium tetrakis(pentafluorophenyl)borate 

Relevant academic research and scientific papers

Reuseable monolithic nanoporous graphite-supported nanocatalysts (Fe, Au, Pt, Pd, Ni, and Rh) from pyrolysis and galvanic transmetalation of ferrocene-based polyamide aerogels

Polyamide aerogels with ferrocene as a monomer repeat unit were prepared in one step from ferrocene dicarboxylic acid and tris(4-isocyanatophenyl)methane. Pyrolysis at ≥800 °C yielded nanoporous carbons doped throughout with crystallites of α-Fe (about 50 nm in diameter), which in turn were shrouded in graphitic ribbons (a path akin to galvanic corrosion, whereas graphitic ribbons separated anodes (α-Fe particles) from cathodes (defects along the ribbons). The new metallic phases formed clusters of smaller crystallites (10-20 nm in diameter) on the graphitic ribbons, leaving behind empty cage-like formations previously occupied by the Fe(0) nanoparticles. All metal-doped carbons were monolithic and over 85% porous. Catalytic activity was demonstrated with the oxidation of benzyl alcohol to benzaldehyde catalyzed with carbon-supported Au or Pt, the reduction of nitrobenzene by hydrazine to aniline catalyzed with carbon-supported Fe, and two Heck coupling reactions of iodobenzene with styrene or butyl acrylate, catalyzed with carbon-supported Pd. The distinguishing feature of those catalysts was that they could be just picked up, for example, with a pair of tweezers, and redeployed in a new reaction mixture immediately, thus bypassing less efficient recovery processes like filtration.

Synthesis of new ferrocene derivatives with a 4,5-dichloroisothiazole fragment

Conjugates of ferrocene and 4,5-dichloroisothiazole were synthesized, where the ferrocene and isothiazole moieties are linked through various structural fragments. The acylation of ferrocene with 4,5- dichloroisothiazole-3-carbonyl chloride gave (4,5-dichloroisothiazol-3-yl) ferrocenyl ketone; the acylation of aminomethylferrocene furnished the corresponding amide. The esterification of ferrocene-1,1′-dicarboxylic acid with 4,5-dichloroisothiazol-3-yl-methanol resulted in the formation of the corresponding ester. The condensation of 1,1′-diacetylferrocene with 4,5-dichloroisothiazole-3-carbaldehyde afforded ferrocenophane containing 4,5-dichloroisothiazole moieties.

Use of Boolean and fuzzy logics in lactose glycocluster research

Fuzzy logic systems can be exploited for defining the degrees of true or false binding between calcium mediated multivalent lactose and peanut agglutinin lectin, which are difficult to define with Boolean logic.

Large-scale preparation of 1,1′-ferrocenedicarboxylic acid, a key compound for the synthesis of 1,1′-disubstituted ferrocene derivatives

Efficient and simple methods for the large-scale preparation of 1,1′-ferrocenedicarboxylic acid, fc(COOH)2, involving the sodium salts of cyclopentadienecarboxylic methyl and ethyl esters, Na(C 5H4COOR) (R = Me, Et), are presented. With fc(COOH) 2 at hand, the syntheses of various 1,1′-disubstituted compounds of the type fcX2 (X = CH2OH, COCl, CON 3, NCO, NHCOOMe, NHBoc, NH2) were optimized and scaled up. The X-ray crystal structures of fc(COOEt)2, fc(NCO) 2·1/2C6H6, and fc(NHCOOMe)2·MeOH are reported.

Ferrocene Macrocyclic Schiff Base Complex: Synthesis, Structure and Recognition Properties for Dual Hg2+ and Cu2+

A probe based on ferrocene structure has been designed, synthesized and elucidated from the single crystal X-ray method. It demonstrated fluorescence response to Hg2+ and Cu2+ in CH3OH. The results indicated that the title complex could be applied in the multianalyte detection. Binding ability of receptor 3 in CH3OH was tested for various cations (Fe3+, Co2+, Cu2+, Zn2+, Cd2+, Hg2+, Pb2+, and Ba2+ in water). The computed binding constants for Hg2+ and Cu2+ indicated a distinct absorbance shift. The receptor is an attractive array due to its distinct absorbance shift profile in a semi-aqueous phase, making it applicable in biology, environmental sciences and material chemistry.

Synthesis and study of cytotoxic activity of 1,2,4-trioxane- and egonol-derived hybrid molecules against Plasmodium falciparum and multidrug-resistant human leukemia cells

Malaria and cancer cause the death of millions of people every year. To combat these two diseases, it is important that new pharmaceutically active compounds have the ability to overcome multidrug resistance in cancer and Plasmodium falciparum strains. In search of effective anti-cancer and anti-malaria hybrids that possess improved properties compared to their parent compounds, a series of novel 1,2,4-trioxane-based hybrids incorporating egonol and/or ferrocene fragments were synthesized and tested in vitro against P. falciparum strains, CCRF-CEM cells and the multidrug-resistant P-glycoprotein-over-expressing CEM/ADR5000 cells. The most active compounds against P. falciparum strains were artesunic acid homodimers 12 and 13 (IC 50 of 0.32 and 0.30 nM, respectively), whereas novel hybrids 7 (1,2,4-trioxane-ferrocene-egonol), 9 (1,2,4-trioxane-ferrocene) and 11 (artesunic acid-egonol) showed a remarkable cytotoxicity toward CCRF-CEM cells (IC50 of 0.07, 0.25 and 0.18 μM, respectively). A cooperative and synergistic effect of the three moieties 1,2,4-trioxane, ferrocene and egonol in hybrid molecule 7 is significant and is obviously stronger than in hybrids 9 (1,2,4-trioxane-ferrocene) and 11 (artesunic acid-egonol), which comprises of only two of the three considered parent compounds. Interestingly, hybrid 9 containing a 1,2,4-trioxane and a ferrocene fragment has shown to be the most effective among the studied hybrids against the tested multidrug-resistant leukemia CEM/ADR5000 cells (IC50 of 0.57 μM) and possesses a degree of cross-resistance of 2.34.

New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids

In our ongoing search for highly active hybrid molecules exceeding their parent compounds in anticancer, antimalaria as well as antiviral activity and being an alternative to the standard drugs, we present the synthesis and biological investigations of 2nd generation 1,2,4-trioxane-ferrocene hybrids. In vitro tests against the CCRF-CEM leukemia cell line revealed di-1,2,4-trioxane-ferrocene hybrid 7 as the most active compound (IC50 of 0.01 μM). Regarding the activity against the multidrug resistant subline CEM/ADR5000, 1,2,4-trioxane-ferrocene hybrid 5 showed a remarkable activity (IC50 of 0.53 μM). Contrary to the antimalaria activity of hybrids 4-8 against Plasmodium falciparum 3D7 strain with slightly higher IC50 values (between 7.2 and 30.2 nM) than that of their parent compound DHA, hybrids 5-7 possessed very promising activity (IC50 values lower than 0.5 μM) against human cytomegalovirus (HCMV). The application of 1,2,4-trioxane-ferrocene hybrids against HCMV is unprecedented and demonstrated here for the first time.

Synthesis, crystal structure and properties of two novel ferrocenophane compounds

The title compounds were synthesized via click reaction. They were characterized by IR, 1H-NMR, elemental analysis, UV, fluorescence in solution were also applied to characterise their photophysical characterization and single-crystal X-ray diffraction analysis. 1,1′-Ferrocene-dicarboxyl-{[(3-methylphenyl)-imino]di-2,1-ethanediyl} 1 (C23H23FeNO4) crystallizes in the monoclinic system, with a = 7.4261(13), b = 29.911(5), c = 9.8426(13) ?, α = 90°, β = 118.251(10)°, γ = 90°, V = 1925.8(5) ?3, 1,1′-Ferrocene-dicarboxyl-{[(2-methylphenyl)-imino]di-2,1-ethanediyl} 2 (C23H23FeNO4) crystallizes in the monoclinic system, with a = 15.4000 (15), b =7.9007 (8), c = 16.0776 (15) ?, α = 90°, β = 94.266 (2)°, γ = 90°, V = 1950.8 (3)? 3, Both 1 and 2 form 3D net structures, which are further linked to form 3D supramolecular net structures via intermolecular C?H···O, C?H···π and C?H···C stacking interactions, respectively. Fluorescent and UV-vis absorption spectra were also investigated.

A functionalized Ag2S molecular architecture: Facile assembly of the atomically precise ferrocene-decorated nanocluster [Ag74S19(dppp)6(fc(C{O}OCH2CH2S)2)18]

A ferrocene-based dithiol 1,1′-[fc(C{O}OCH2CH2SH)2] has been prepared and treated with a AgI salt to form the stable dithiolate compound [fc(C{O}OCH2CH2SAg)2]n (fc=[Fe

Synthesis of ferrocenylated-aminopyridines and ferrocenylated-aminothiazoles and their anti-migration and burning rate catalytic properties

For overcoming the migration problems of ferrocene (Fc)-based burning rate catalysts (BRCs) as well as for enhancing burning rate (BR) of ammonium perchlorate (AP)-based propellants, ferrocenylated-amino pyridines (AP-Fcs) and ferrocenylated-amino thiazol