The synthesis and characterisation of some 2,7-diazaphenanthrene derivatives

Article abstract of DOI:10.1002/jhet.5570200453

2,7-Diazaphenanthrene was synthesised in moderate yield by the modified Pomeranz-Fritsch reaction by condensing diethoxyethanal with 1,4-benzenebismethanamine, followed by ring closure with 20% oleum, and its spectral characteristics recorded. A similar reaction with diethyl 1,4-benzenebis(3-aminopropanoate) gave either 2,7-diaza-1,8-dimethylphenanthrene or 2,7-diaza-1,8-phenanthrenebis(methylsulphonic acid), depending on the conditions of the ring closure reaction. The bis methiodides of these compounds were tested for phospholipase A₂ inhibitory action but were found to be inactive.