14850-87-4

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 613-94-5 benzoic acid hydrazide 
• 93-89-0 benzoic acid ethyl ester 
• 91099-00-2 2'-(4-methoxybenzyl)benzohydrazide 
• 93-58-3 benzoic acid methyl ester 
• 65-85-0 benzoic acid 

Downstream Products

• 91099-00-2 2'-(4-methoxybenzyl)benzohydrazide 
• 842-79-5 2-(4-methoxy-phenyl)-5-phenyl-[1,3,4]oxadiazole 
• 2299-73-2 N,N-bis(4-methoxybenzylidene)hydrazine 
• 98-88-4 benzoyl chloride 
• 69341-73-7 1-chloro-4-(4-methoxyphenyl)-1-phenyl-2,3-diazabutadiene 
• 92311-70-1 N-[3-Chloro-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl]-benzamide 
• 77420-69-0 N-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-N'-[1-phenyl-1-thiocyanato-meth-(Z)-ylidene]-hydrazine 
• 85759-88-2 (C₅H₅)TiCl₂(CH₃OC₆H₄)CHNNC(O)C₆H₅ 
• 85767-98-2 (C₅H₅)TiCl((CH₃OC₆H₄)CHNNC(O)C₆H₅)2 
• 32983-58-7 Ni(p-MeOC₆H₄CHNNCOPh)2 
• 1124127-49-6 dimethyl 2-[N-benzoyl-N'-(4-methoxy-benzylidene)-hydrazino]-3-(cyclohexyliminomethylene)succinate 
• 554447-15-3 (S)-benzoic acid N'-[1-(4-methoxyphenyl)but-3-enyl]hydrazide 
• 1236179-25-1 (3,4-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)(phenyl)methanone 
• 1236179-35-3 (3-isopropyl-4-phenyl-4,5-dihydro-1H-pyrazol-1-yl)(phenyl)methanone 

Relevant academic research and scientific papers

Synthesis and Fluorescence Properties of Eu3+, Tb3+ Complexes with Schiff Base Derivatives

Novel Schiff base ligands derived from N′-benzylidene-benzohydrazide (substituted by-H,-CH3,-OCH3,-Cl) and 2-chloro-N-phenylacetamide were synthesized. The solid complexes of rare earth (Eu, Tb) nitrate with these Schiff base ligands

Synthesis, Spectral Characterization, Crystal Structure, Thermal Studies and Hirshfeld Surface Analysis of Novel Dichlorodi-(E)-N′-(4-methoxybenzylidene)benzohydrazide Manganese(II) Complex

A novel dichlorodi(E)-N′-(4-methoxybenzylidene)benzohydrazide manganese(II) (ENMB-Mn) complex has been successfully synthesized using (E)-N′-(4-methoxybenzylidene)benzohydrazide (ENMB) as ligand. The structure of the ENMB-Mn complex was studied by single crystal X-ray diffraction, UV-Visible, FTIR, thermogravimetric analysis (TGA) and Hirshfeld surface analysis. Results of single crystal X-ray diffraction found that the structure of ENMB-Mn complex crystal is triclinic with space group P-1 and lattice parameters of unit cell a, b and c values were 7.1900 ?, 8.9094 ? and 11.8130 ?, respectively. The structure of ENMB-Mn complex clearly indicates complete octahedral geometry [Mn(ENMB)2Cl2] with manganese(II) ion, where the ENMB and chlorine atoms ratio is 1:2:2, respectively. Further, the molecular properties like Hirshfeld surface analysis mapping are reported.

p-methoxybenzaldehyde benzoylhydrazone monohydrate

The crystal structure of the title compound, C15H14N2O2·H2O, is in the keto tautomeric form and the configuration at the azomethine C double bond N double bond is E. The molecule is non-planar, with a dihedral angle of 27.3 (1)° between the aromatic rings. The crystal structure is stabilized by extensive hydrogen bonding involving the water molecule and hydrazone moiety.

Vibrational spectroscopy investigation and density functional theory calculations on (E)-N′-(4-methoxybenzylidene) benzohydrazide

The FT-IR, FT-Raman and UV-Vis spectra of the Schiff base compound (E)-N′-(4-methoxybenzylidene) benzohydrazide (MBBH) have been recorded and analyzed. The optimized geometrical parameters were calculated. The complete vibrational assignments were perform

Modulation of estrogen-related receptors subtype selectivity: Conversion of an ERRβ/γ selective agonist to ERRα/β/γ pan agonists

Estrogen Related Receptors (ERRs) are key regulators of energy homeostasis and play important role in the etiology of metabolic disorders, skeletal muscle related disorders, and neurodegenerative diseases. Among the three ERR isoforms, ERRα emerged as a potential drug target for metabolic and neurodegenerative diseases. Although ERRβ/γ selective agonist chemical tools have been identified, there are no chemical tools that effectively target ERRα agonism. We successfully engineered high affinity ERRα agonism into a chemical scaffold that displays selective ERRβ/γ agonist activity (GSK4716), providing novel ERRα/β/γ pan agonists that can be used as tools to probe the physiological roles of these nuclear receptors. We identified the structural requirements to enhance selectivity toward ERRα. Molecular modeling shows that our novel modulators have favorable binding modes in the LBP of ERRα and can induce conformational changes where Phe328 that originally occupies the pocket is dislocated to accommodate the ligands in a rather small cavity. The best agonists up-regulated the expression of target genes PGC-1α and PGC-1β, which are necessary to achieve maximal mitochondrial biogenesis. Moreover, they increased the mRNA levels of PDK4, which play an important role in energy homeostasis.

Synthesis and biological evaluation in vitro and in silico of N-propionyl-N′-benzeneacylhydrazone derivatives as cruzain inhibitors of Trypanosoma cruzi

Abstract: An N-acylhydrazone scaffold has been used to develop new drugs with diverse biological activities, including trypanocidal activity against different strains of Trypanosoma cruzi. However, their mechanism of action is not clear, although in T. cr

Sodium hypochlorite-mediated synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from hydrazides and aldehydes

[Figure not available: see fulltext.] A simple and convenient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed. Structurally divergent symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles can be obtained in moderate to high yields via NaOCl-mediated oxidative cyclization of N-acylhydrazones, generated in situ from aliphatic and aromatic hydrazides and aldehydes.

Planar AIEgens with Enhanced Solid-State Luminescence and ROS Generation for Multidrug-Resistant Bacteria Treatment

Planar luminogens have encountered difficulties in overcoming intrinsic aggregation-caused emission quenching by intermolecular π-π stacking interactions. Although excited-state double-bond reorganization (ESDBR) can guide us on designing planar aggregati

Experimental and Theoretical Studies on the Mechanism of DDQ-Mediated Oxidative Cyclization of N-Aroylhydrazones

The controversial single-electron-transfer process, frequently proposed in many 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-mediated reactions, was investigated experimentally and theoretically using the oxidative cyclization of aroylhydrazone with DDQ. DDQ-mediated oxadiazole formation involves several processes, including cyclization to form an oxadiazole ring and N-H bond cleavage, either by proton, hydride, or hydrogen atom transfer. The detailed mechanistic study using the M06-2X density functional theory, and the 6-31+G(d,p) basis set, suggests that the pathways involving radical ion pair (RIP) intermediates, which resulted from single-electron transfer (SET), were found to be energetically nearly identical to the pathway without the SET. The substituent-dependent reactivity of oxadiazole formation was consistent with the free energy profiles of both pathways, with or without the SET. This result indicates that in addition to the electron-transfer pathway, the nucleophilic addition/elimination pathway for DDQ should be considered as a possible mechanism of the oxidative transformation reaction using DDQ.

Indoline Catalyzed Acylhydrazone/Oxime Condensation under Neutral Aqueous Conditions

Acylhydrazones formation has been widely applied in materials science and biolabeling. However, their sluggish condensation rate under neutral conditions limits its application. Herein, indolines with electron-donating groups are reported as a new catalyst scaffold, which can catalyze acylhydrazone, hydrazone, and oxime formation via an iminium ion intermediate. This new type of catalyst showed up to 15-fold rate enhancement over the traditional anilinecatalyzed reaction at neutral conditions. The identified indoline catalyst was successfully applied in hydrogel formation.