SYNTHESIS OF PROSTACYCLIN ANALOGUE (4-OXO-PGI2)

DOI: 10.1246/cl.1983.1249

Source and publish data:

Chemistry Letters p. 1249 - 1250 (1983)

Update date:2022-08-04

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Authors:

Ono, Toshio

Sibasaka, Isao

Nokami, Junzo

Wakabayashi, Shoji

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Article abstract of DOI:10.1246/cl.1983.1249

A stable prostaglandin I2 (PGI2) analogue, 4-oxo-PGI2 was synthesized by employing Wittig-like olefin synthesis due to the reaction of a carbanion linked to an electron withdrowing group with a lactone carbonyl group.

Full text of DOI:10.1246/cl.1983.1249

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