Journal of Organic Chemistry p. 1488 - 1494 (1984)
Update date:2022-08-04
Topics:
Makosza, Mieczyslaw
Golinski, Jerzy
Baran, Janusz
Carbanions of α-chloroalkyl phenyl sulfones and N,N-dialkyl-α-chloroalkanesulfonamides react with nitrobenzenes to effect direct nucleophilic replacement of hydrogen ortho and para to the nitro group, with vicarious loss of chloride anion, to give the corresponding nitrobenzylsulfonyl derivatives.The reaction occurs much more rapidly than the replacement of such good leaving groups as halogen, methoxy, and phenoxy.Most substituents in the nitrobenzene ring do not interfere with the reaction.The effect of substituents in the nitrobenzene and the carbanion on the orientation of the substitution is discussed.
View Morewebsite:http://www.mascot-ie.com
Contact:86-519-85010339
Address:B-802,XingBei Building,391#,Tongjiang Middle Road New District,Changzhou,JS,China
ShenZhen InnoSyn Biotech Co.,Ltd
website:http://www.innosyns.com
Contact:+86-755-28351685
Address:Floor 5 & 6, Building A1, HAIKEXING Strategic Innovative Industrial Park, 16 BaoShan Road, PingShan District
Changsha Yihai Chemical Technology Co.,ltd
website:http://www.cs-yihai.com/
Contact:0731- 85620465
Address:Room 23005, unit 2, the northern building of Xiangsong international building , NO.259 Shaoshan Road , Changsha , Hunan, China.(mainland)
Heliosense Biotechnologies, Inc.
Contact:+86-592-5667290
Address:Xiamen Torch Hi-tech Zone Venture Weiye Building S506
Hebei Think-Do Environment Co., Ltd
website:http://www.thinkdo-environment.com
Contact:0311-86510809
Address:No 6, Shilian Middle Street, Circular Chemical Industry Park
Doi:10.1016/S0040-4039(00)94232-1
(1983)Doi:10.1074/jbc.M112.355503
(2012)Doi:10.1002/chem.200501058
(2006)Doi:10.1021/ol060490l
(2006)Doi:10.1021/jm0510732
(2006)Doi:10.1016/j.jorganchem.2006.01.020
(2006)