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Inhibition of Arabinose 5-Phosphate Isomerase. An Approach to the Inhibition of Bacterial Lipopolysaccharide Biosynthesis

DOI: 10.1021/jm00372a003

Source and publish data:

Journal of Medicinal Chemistry p. 717 - 726 (1984)

Update date:2022-08-03

Topics:

Authors:

Bigham, Eric C.Bigham, Eric C.

Gragg, Charles E.Gragg, Charles E.

Hall, William R.Hall, William R.

Kelsey, John E.Kelsey, John E.

Mallory, William R.Mallory, William R.

et al.et al.

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Article abstract of DOI:10.1021/jm00372a003

Arabinose 5-phosphate (A5P) isomerase is a key enzyme in the biosynthesis of liposaccharide, an essential component of the outer membrane of Gram-negative bacteria.The mechanism of the isomerase is envisioned to involve an enediol intermediate.A series of

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Full text of DOI:10.1021/jm00372a003

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