Inhibition of Arabinose 5-Phosphate Isomerase. An Approach to the Inhibition of Bacterial Lipopolysaccharide Biosynthesis

DOI: 10.1021/jm00372a003

Source and publish data:

Journal of Medicinal Chemistry p. 717 - 726 (1984)

Update date:2022-08-03

Topics:

Authors:

Bigham, Eric C.

Gragg, Charles E.

Hall, William R.

Kelsey, John E.

Mallory, William R.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00372a003

Arabinose 5-phosphate (A5P) isomerase is a key enzyme in the biosynthesis of liposaccharide, an essential component of the outer membrane of Gram-negative bacteria.The mechanism of the isomerase is envisioned to involve an enediol intermediate.A series of

Full text of DOI:10.1021/jm00372a003

Products guided by the article

Product name:Phosphoric acid (3aR,4R,6aR)-2,2-dimethyl-6-oxo-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester diphenyl ester

Cas No:89747-60-4

R&D Labs maybe for 89747-60-4

KangZhiYuan Pharmaceutical Company Limited

Contact:(Sabrina)86-20-85273232

Address:4th floor, building B, Dadi industry zone, Tangxia, Tianhe, Guangzhou, China
Beijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)

Contact:010-52876516

Address:tongzhoubeiyuan
Zhejiang kehong chemical co., ltd

Contact:0086-575-85522000

Address:xiner center RD binhai industrial zone shaoxing zhejiang province P.R.China,312073
SHANGHAI T&W PHARMACEUTICAL CO., LTD.

website:http://www.trustwe.com

Contact:+86-21-61551413

Address:601, No. 1, 2277 Nong, Zu Chongzhi Road, Zhangjiang Hightech. Park, Pudong
Zibo Kunran Enterprises Co. LTD

website:http://www.kunranchem.com

Contact:0086 533 5200669

Address:No. 96 Jinjing Avenue, Zibo, Shandong, China

Relevant to this article

Haloanilino derivatives of pyrimidines, purines, and purine nucleoside analogs: Synthesis and activity against human cytomegalovirus

Doi:10.1021/jm00010a026
(1995)
New Routes To Molybdenum and Tungsten Carbyne Complexes (M = Mo or W, R = SnPh3; M = W, R = H)

Doi:10.1039/c39950000515
(1995)
Sequential Addition of Phosphine to Alkynes for the Selective Synthesis of 1,2-Diphosphinoethanes under Catalysis. Well-Defined NHC-Copper Phosphides vs in Situ CuCl₂/NHC Catalyst

Doi:10.1021/acs.organomet.6b00854
(2017)
Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists

Doi:10.1021/jm9608117
(1997)
Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective δ opioid agonists, based on an extension of the message-address concept

Doi:10.1021/jm9608218
(1997)
Synthesis and properties of a through-space-conjugated dimer

Doi:10.1246/cl.131059
(2014)

Article Doi