Journal of Organic Chemistry p. 2301 - 2309 (1984)
Update date:2022-08-04
Topics:
Kozikowski, Alan P.
Stein, Philip D.
A formal total synthesis of the prostaglandin F2α is reported which is based on the reaction of a nitrile oxide, generated by th sodium hypochlorite oxidation of an oxime, with a tethered olefin.The present study reveals the importance of an existing ring structure to control both the kinetics and the stereochemical course of the cycloaddition process.The possibility of carrying out the present synthesis in a chiral-selective fashion through employment of a chiral epoxide is also discussed.
View MoreNantong Kaixin Pharma Chemical Co.,Ltd.
Contact:86-513-85250786
Address:2-1103 Huachen Mansion, 111 Gongnong Road,Nantong, Jiangsu, China
Shandong Yaroma Perfumery Co., Ltd.
Contact:+86- 531- 88024598
Address:7-702 Caizhi Central, 59 Gong Ye South Road, Jinan City,250101, P. R. China
website:http://www.simagchem.com
Contact:+86-592-2680277
Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China
Hebei Kangtai Pharmaceutical Co.,Ltd
Contact:+86-0317-3512963
Address:Wugang Road,Mengcun of Cangzhou City,Hebei Province ,China
Contact:+44 (0)161 367 9441
Address:
Doi:10.1016/j.tetlet.2006.04.078
(2006)Doi:10.1021/acs.jmedchem.6b00757
(2016)Doi:10.1016/S0040-4039(01)80060-5
(1984)Doi:10.1055/s-2006-939053
(2006)Doi:10.1039/jr9640001201
(1964)Doi:10.1021/jm501527z
(2014)
