A metal-free tandem demethylenation/C(sp2)-H cycloamination process of N -Benzyl-2-aminopyridines via C-C and C-N bond cleavage

DOI: 10.1021/ol4015656

Source and publish data:

Organic Letters p. 3476 - 3479 (2013)

Update date:2022-08-04

Topics:

Authors:

Liang, Dongdong

He, Yimiao

Liu, Lanying

Zhu, Qiang

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Article abstract of DOI:10.1021/ol4015656

A mild, metal-free synthesis of pyrido[1,2-a]benzimidazoles starting with N-benzyl-2-aminopyridines, which employs PhI(OPiv)₂ as a stoichiometric oxidant, has been developed. The process is initiated by an unusual PhI(OPiv)₂-mediated ipso S_EAr reaction, followed by solvent-assisted C-C and C-N bond cleavage.

Full text of DOI:10.1021/ol4015656

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