Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPARγ ligands (I)

Article abstract of DOI:10.1016/j.bmcl.2006.06.093

MCSS and LeapFrog, two de novo drug design programs, were used for the novel indole-based PPARγ ligands' study. The designed compounds were synthesized and tested for the PPARγ protein binding activities in vitro. Out of the compounds that were synthesize