13269-91-5Relevant academic research and scientific papers
Experimental and computational study of metal-free Br?nsted acidic ionic liquid catalyzed benzylic C(sp3)–H bond activation and C–N, C–C cross couplings
Valiyev, Isa,Abdullayev, Yusif,Yagubova, Sevinj,Baybekov, Shamkhal,Salmanov, Cavanshir,Autschbach, Jochen
, p. 410 - 419 (2019)
Metal and solvent free synthesis of tetrasubstituted imidazoles and tetrasubstituted pyrazines from 1,2-diketones and aliphatic amines is studied experimentally and computationally. Various ionic liquids (ILs) are taken as a catalyst in 10 mol% for the re
A solvent-free synthesis of 1,2,4,5-tetrasubstituted imidazoles using molecular iodine as catalyst
Ren, Yi-Ming,Cai, Chun
, p. 133 - 134 (2010)
An efficient method for the synthesis of 1,2,4,5-tetrasubstituted imidazoles by three-component condensation of benzil, benzonitrile derivatives and primary amines under solvent-free conditions using molecular iodine as catalyst is described with high product yields. The significant features of the iodine-catalysed condensation are operational simplicity, inexpensive reagents, high yield of products and use of non-toxic reagents.
One-pot synthesis of tetra-substituted imidazoles on silica gel under microwave irradiation
Xu, Yu,Liu, Yan-Zhi,Rui, Lei,Liu, Lei,Guo, Qing-Xiang
, p. 87 - 93 (2004)
A new procedure for synthesis of tetra-substituted imidazoles was developed. A series of imidazole derivatives including six new compounds were synthesized by this procedure via condensation of benzoin, aromatic aldehyde, amine and ammonium acetate in the presence of silica gel under solvent-free microwave irradiation.
Carbon-based solid acid as an efficient and reusable catalyst for one-pot synthesis of tetrasubstituted imidazoles under solvent-free conditions
Tavakoli-Hoseini, Niloofar,Davoodnia, Abolghasem
, p. 203 - 206 (2011)
Carbon-based solid acid catalyst was found to be highly efficient, eco-friendly and recyclable heterogeneous catalyst for the multicomponent reaction of benzil, aromatic aldehyde, primary amine and ammonium acetate, giving rise to 1,2,4,5-tetrasubstituted imidazoles in good to excellent yields. The present methodology offers several advantages, such as high yields, short reaction time, mild reaction condition and a recyclable catalyst with a very easy work up. Carbon-based solid acid catalyst was found to be highly efficient, eco-friendly and recyclable heterogeneous catalyst for the multicomponent reaction of benzil, aromatic aldehyde, primary amine and ammonium acetate for the synthesis of 1,2,4,5- tetrasubstituted imidazoles in good to excellent yields. The present methodology offers several advantages, such as high yields, short reaction time, mild reaction condition and a recyclable catalyst with a very easy work up. Copyright
A novel one-pot synthesis of tetrasubstituted imidazoles under solvent-free conditions and microwave irradiation
Balalaie, Saeed,Hashemi, Mohammed M.,Akhbari, Maryam
, p. 1709 - 1711 (2003)
The one-pot, three-component condensation of benzil, benzonitrile derivatives and primary amines on the surface of silica gel under solvent-free conditions and microwave irradiation provided tetrasubstituted imidazoles in high yields.
Increased SBA-15-SO3H catalytic activity through hydrophilic/hydrophobic fluoroalkyl-chained alcohols (RFOH/SBA-15-Pr-SO3H)
Rostamnia, Sadegh,Doustkhah, Esmail
, p. 1345 - 1347 (2015)
A superior catalytic activity for the SBA-15-functionalized sulfonic acid containing fluoroalkyl chain alcohols (RFOH/SBA-15-Pr-SO3H adduct) is presented for the synthesis of highly substituted imidazoles. The advantages of this method include low catalyst loading, simple procedure, excellent yields, recyclability of catalyst, and short reaction times.
One-pot synthesis of polysubstituted imidazoles in a bronsted acidic deep eutectic solvent
Wang, Liang,Zhong, Xia,Zhou, Min,Zhou, Wei-You,Chen, Qun,He, Ming-Yang
, p. 236 - 238 (2013)
A Bronsted acidic deep eutectic solvent based on choline chloride and p-toluenesulfonic acid was prepared and was found to be effective for the one-pot synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles with high yields. In addition, the deep eutectic solvent is non-toxic, cost-effective and recyclable.
Silica coated magnetic NiFe2O4 nanoparticle supported phosphomolybdic acid; Synthesis, preparation and its application as a heterogeneous and recyclable catalyst for the one-pot synthesis of tri- and tetra-substituted imidazoles under solvent free conditions
Maleki, Behrooz,Eshghi, Hossein,Khojastehnezhad, Amir,Tayebee, Reza,Ashrafi, Samaneh Sedigh,Kahoo, Golnoosh Esmailian,Moeinpour, Farid
, p. 64850 - 64857 (2015)
In this research, a magnetically-recoverable catalyst (NiFe2O4@SiO2-H3PMo12O40) was prepared by supporting phosphomolybdic acid (H3PMo12O40) onto silica-coated NiFe2O4 nanoparticles. The prepared sample was characterized by FT-IR, TEM, SEM and VSM techniques and then the catalytic activity of this catalyst was investigated in the synthesis of tri- and tetra-substituted imidazole derivatives. More importantly, the catalyst was easily isolated from the reaction mixture by a magnetic bar and reused at least ten times without significant degradation in its activity.
Amberlyst A-15: Reusable catalyst for the synthesis of 2,4,5-trisubstituted and 1,2,4,5-Tetrasubstituted-1H-Imidazoles under MW irradiation
Pandit, Shivaji S.,Bhalerao, Swapnil K.,Aher, Uddhav S.,Adhav, Gorakshanath L.,Pandit, Vikram U.
, p. 421 - 426 (2011)
One-pot multi-component condensation of benzyl, aldehydes, ammonium acetate and primary amines were used for synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted-1H-imidazole derivatives underMWradiation using amberlyst A-15 as a catalysts. This catalyst has several advantages (simple work-up, low cost and reusability) . Indian Academy of Sciences.
BF3·SiO2: an efficient reagent system for the one-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles
Sadeghi, Bahareh,Mirjalili, Bi Bi Fatemeh,Hashemi, Mohammad M.
, p. 2575 - 2577 (2008)
Silica-supported boron trifluoride (BF3·SiO2) is an efficient, readily available and reusable catalyst for the synthesis of 1,2,4,5-tetrasubstituted imidazoles using benzil, an aromatic aldehyde and an amine in the presence of ammonium acetate. This one-pot procedure is very simple, affording good to excellent yields.
