Preparation of 1-[(3-trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-pyridinone derivatives from aza annulation reactions of N-[(3-trifluoromethyl)phenyl]- substituted enaminones

Article abstract of DOI:10.1071/CH05188

Reaction of 3-trifluoromethylaniline with the 1,3-diketones 1a?1c and 5a?5d affords the N-[(3-trifluoromethyl)phenyl]-substituted enaminones 2a?2c and 6a?6d. Reaction of 2a with the acryloyl chloride derivatives 3a?3c gives the 1-[(3-trifluoromethyl)pheny