4-Bromo-1-methoxy-N-[2-(4-aryl-1-piperazinyl)ethyl]-2- naphthalenecarboxamides: Selective dopamine D3 receptor partial agonists

Article abstract of DOI:10.1016/0960-894X(96)00231-4

A series of 4-bromo-1-methoxy-N-[2-(4-aryl-1-piperazinyl)ethyl]-2- naphthalenecarboxamide dopamine (DA) D₃ receptor agonists has been identified. These compounds were found to be selective for DA D₃ over D₂ receptors and were shown to be partial to full agonists as measured by stimulation of mitogenesis in D₃-transfected CHO p-5 cells.