Studies on the Synthesis of the Antitumor Agent CC-1065. Synthesis of the Cyclopropapyrroloindole Portion

DOI: 10.1039/c39840000389

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 389 - 390 (1984)

Update date:2022-08-04

Topics:

Authors:

Magnus, Philip

Gallagher, Timothy

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/c39840000389

Using a regioselective Mannich reaction the 3,3'-bipyrrole (4) is converted into the acid chloride (10), which is transformed into the tricyclic phenol (11); selective reduction of (11) using triethylsilane in trifluoroacetic acid gives (12), which is con

Full text of DOI:10.1039/c39840000389

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:6-Benzenesulfonyl-5-hydroxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indole-1-carboxylic acid ethyl ester

Cas No:91534-33-7

R&D Labs maybe for 91534-33-7

Suzhou HeChuang Chemical Co.,Ltd.

Contact:+86-512-88800520

Address:No.9 Guanchao Rd,Changshu Advanced Materials Industy Park
jiangsu hualin chemical co.,ltd.

Contact:86-25-87787402

Address:jaingsu,china
Xinji City Taida Sinopec Co., Ltd.

Contact:0086-311-85341278

Address:No.6, Nanhua Road,Xinji City Road,Hebei Province,China
Weifang Arylchem Chemical Co., LTD

Contact:86-536-5217866

Address:Development Zone, Shouguang, Shandong Province

Relevant to this article

Total syntheses of the tylophora alkaloids cryptopleurine, (-)-antofine, (-)-tylophorine, and (-)-ficuseptine C

Doi:10.1002/chem.200600592
(2006)
Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents

Doi:10.1016/j.bmcl.2007.05.029
(2007)
Tandem hydrogenation and condensation of fluorinated α,β-unsaturated ketones with primary amines, catalyzed by nickel

Doi:10.1039/c5dt02366a
(2015)
Factors controlling, the selenium-induced cyclizations of alkenyl hydrazines to pyridazine or pyrrolidinamine derivatives

Doi:10.1016/S0040-4020(97)00670-4
(1997)
Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABA(A) receptors

Doi:10.1021/jm960304p
(1996)
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, induces the production of anti-inflammatory cyclodepsipeptides from Beauveria felina

Doi:10.1021/np400143j
(2013)

Article Doi