Latent alkyl isocyanates as inhibitors of aldehyde dehydrogenase in vivo

Article abstract of DOI:10.1021/jm00050a018

On the basis of our previous observation that N¹-alkyl substituted chlorpropamide derivatives when administered to rats nonenzymatically eliminated n-propyl isocyanate, a known inhibitor of aldehyde dehydrogenase (AlDH), we have synthesized oth