Journal of Coordination Chemistry p. 3071 - 3082 (2010)
Update date:2022-08-04
Topics:
Sharma, Krishna K.
Singh, Ritu
Fahmi, Nighat
Singh
Two isoniazid Schiff bases, N-isonicotinamido-2-furanketimine (INH-F 1) and N-isonicotinamido-5-methyl-2-furanketimine (INH-F 2), possessing potential N and O coordination sites have been prepared by the reaction of isoniazid with 2-acetylfuran and 2-acetyl-5-methylfuran, respectively. Complexes of Pd(II) and Pt(II) have been prepared and characterized by elemental analyses, melting point determinations and electronic, infrared, 1H NMR, 13C NMR spectral studies, and X-ray powder diffraction studies. In all the complexes, the monobasic bidentate nature of the ligand is evident. Antibacterial and antifungal studies of these compounds against various pathogenic bacterial and fungal strains have been carried out. Both the ligands and their metal chelates were active against all the microbial strains investigated. However, the chelates were found to be more active than the ligands. The antimycobacterial activity of the ligands and their metal complexes has been evaluated against Mycobacterium smegmatis, which showed clear enhancement in this activity upon metal complexation with Schiff bases.
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