5-Cinnamoyl-6-aminouracil derivatives as novel anticancer agents. Synthesis, biological evaluation, and structure-activity relationships

DOI: 10.1021/jm00382a020

Source and publish data:

Journal of Medicinal Chemistry p. 497 - 502 (1985)

Update date:2022-08-02

Topics:

Authors:

Bernier Bernier

Henichart

Warin Warin

Trentesaux

Jardillier

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Article abstract of DOI:10.1021/jm00382a020

A biological evaluation in the series of 5-cinnamoyl-6-aminouracils has been undertaken. These compounds have been found to be in an extended planar conformation fitting well with a possible stacking interaction between the nucleic bases of DNA; thus an e

Full text of DOI:10.1021/jm00382a020

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