Pyridinylimidazole inhibitors of Tie2 kinase

DOI: 10.1016/j.bmcl.2007.06.068

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 4756 - 4760 (2007)

Update date:2022-09-26

Topics:

Authors:

Semones, Marcus

Feng, Yanhong

Johnson, Neil

Adams, Jerry L.

Winkler, Jim

Hansbury, Michael

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.bmcl.2007.06.068

This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOP

Full text of DOI:10.1016/j.bmcl.2007.06.068

Products guided by the article

Product name:C₁₉H₁₇NO₂

Cas No:948557-49-1

R&D Labs maybe for 948557-49-1

Shanxi Tongji Pharmaceuticals Co., Ltd.

Contact:+86-359-3024784

Address:Xikuang South Road, Ruicheng County , Shanxi
Antimex Chemical Limied

website:http://www.antimex.com

Contact:0086-21-50563169

Address:Room1027,No.Jinyu Road,Pudong
Innua Petrochem Ltd.

Contact:+1-284-4950244

Address:Box 3069, Road Town, Tortola, British Virgin Islands
Shandong Hongxiang Zinc Co., Ltd

Contact:086-0311-66187879

Address:DaWang developing zone
Beyond Pharmaceutical Co., Ltd

Contact:+86-571-8195-3185

Address:No. 13-1, Liansheng Road, Yuhang District

Relevant to this article

Synthesis of 4-aminopyrido[3,2-b]indole derivatives

Doi:10.1007/s11172-006-0407-8
(2006)
Synthesis of 2,3,6,11-tetramethoxy-5(12H)-naphthacenone as an analogue of tetracycline.

Doi:10.1021/jm50018a007
(1961)
Doi:10.1002/anie.200701733
(2007)
Protiodesilylation of 3-trimethylsilyl-2-thiabicyclo[2.2.1]hept-5-enes and derivatives: A stereochemical study

Doi:10.1016/0040-4020(96)00032-4
(1996)
HETEROALICYCLIC AMINOALKANOL. II. REACTIONS OF DL-2-PIPERIDIME-METHANOL

Doi:10.1248/cpb.13.241
(1965)
Effect of chelators on the pharmacokinetics of ^99mTc-labeled imaging agents for the prostate-specific membrane antigen (PSMA)

Doi:10.1021/jm400823w
(2013)

Article Doi