Studies on antitumor agents. 8. Antitumor activities of O-alkyl derivatives of 2'-deoxy-5-(trifluoromethyl)uridine and 2'-deoxy-5-fluorouridine

DOI: 10.1021/jm00121a025

Source and publish data:

Journal of Medicinal Chemistry p. 136 - 139 (1989)

Update date:2022-08-05

Topics:

Authors:

Yamashita

Takeda Takeda

Matsumoto

Unemi Unemi

Yasumoto

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00121a025

O-Benzyl and O-ethyl derivatives of 2'-deoxy-5-(trifluoromethyl)uridine (F₃Thd) and 2'-deoxy-5-fluorouridine (FUdR) were synthesized. The oral antitumor activity of the compounds against sarcoma 180 in mice was examined. The 5'-O-ethyl (3b), 3'

Full text of DOI:10.1021/jm00121a025

Products guided by the article

Product name:3-benzoyl-2'-deoxy-3'-O-(4-methoxybenzyl)-5-trifluoromethyluridine

Cas No:95969-58-7

R&D Labs maybe for 95969-58-7

Angelisun(Chongqing) Pharmaceutical Co., LTD.

Contact:+86-23-68030926-816

Address:D1-7 Tech & Entrepreneurs Park, Kecheng Road, Erlang Hi-Tech Areas, Chongqing, China
Tianjin Chemsyntech Chemical Co., Ltd

Contact:+86-22-60872258

Address:Haitai green industry base in Tianjin, K1,5-601
New Forms

Contact:+31-24-3886056

Address:Binderskampweg 29 Unit 36
Jinan Aery Pharmaceutical Co,.Ltd

Contact:+8653181263406

Address:1-1916,Building1 Fenghuang SOHO,Fenghuang Road,High-tech Zone,Jinan,Shandong
Shanghai Hanshare Industry Co.,Ltd.

Contact:86 21 20960688

Address:RM902-903,Building E, Wanda Plaza,No.26,Zhoukang Road, Pudong District, Shanghai, China

Relevant to this article

Hydrogen Cyanide Chemistry. 9. Cycloaddition Reactions and Nitrenium Ion Type Reactivity of Diiminosuccinonitrile

Doi:10.1021/jo00179a013
(1984)
Mechanisic Studies of 2-Lithio-1,3-dithiane Reactions with Radical Probes

Doi:10.1021/jo00179a038
(1984)
Enantioselective total synthesis of FD-891

Doi:10.1021/ja060018v
(2006)
Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: Potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis

Doi:10.1021/jm060055x
(2006)
Effects of ortho- and para-ring activation on the kinetics of S _NAr reactions of 1-chloro-2-nitro- and 1-phenoxy-2-nitrobenzenes with aliphatic amines in acetonitrile

Doi:10.1002/ejoc.200500774
(2006)
In vivo optical imaging of amyloid aggregates in brain: Design of fluorescent markers

Doi:10.1002/anie.200500845
(2005)

Article Doi