Studies on antitumor agents. 8. Antitumor activities of O-alkyl derivatives of 2'-deoxy-5-(trifluoromethyl)uridine and 2'-deoxy-5-fluorouridine

DOI: 10.1021/jm00121a025

Source and publish data:

Journal of Medicinal Chemistry p. 136 - 139 (1989)

Update date:2022-08-05

Topics:

Authors:

Yamashita

Takeda Takeda

Matsumoto

Unemi Unemi

Yasumoto

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Article abstract of DOI:10.1021/jm00121a025

O-Benzyl and O-ethyl derivatives of 2'-deoxy-5-(trifluoromethyl)uridine (F₃Thd) and 2'-deoxy-5-fluorouridine (FUdR) were synthesized. The oral antitumor activity of the compounds against sarcoma 180 in mice was examined. The 5'-O-ethyl (3b), 3'

Full text of DOI:10.1021/jm00121a025

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