Journal of Organic Chemistry p. 3843 - 3845 (1985)
Update date:2022-08-03
Topics:
Bates, Hans, Aaron
Farina, James
The hypotensive oudenone (1) has been synthesized through the intermediacy of oxonium ion 4.Acid-catalyzed C-alkylation of 1,3-cyclopentanedione (3) with 5-propyltetrahydro-2-furanol (6b) afforded dihydrooudenone 2b.In contrast, alkylation of 3 with 2-chloro-5-propyltetrahydrofuran (7b) was unsuccessful.Unsaturation was introduced into 2b by treatment with N-(phenylthio)succinimide to produce 10 followed by oxidation to the corresponding sulfoxide and elimination of phenylsulfenic acid, which produced oudenone(1).
View MoreShanghai doly chemical Co.,Ltd
Contact:+86-21-34716221
Address:No.328,WuHe Roard,MinHang,ShangHai China
Jiaxing Trustworthy Import And Export Co.,Ltd
Contact:+86-573-82030555
Address:Room 1202, Unit B, Charming plaza,No.1558 East Zhongshan Road , Jiaxing City, Zhejiang Province, China.
Contact:+36(21)2523420
Address:Head office: 1102 Budapest, SZENT LASZLO TER 24/B. 1/1., HUNGARY / CHINA
Contact:+86-518-81061113
Address:No. 8 Lingzhou Road, Lianyungang, Jiangsu, China
Shanghai Send Pharmaceutical Technology Co., Ltd.
website:http://www.shsendpharma.com
Contact:021-58088081, +8613585868794
Address::Room A601, Building 1,NO. 800 Qingdai Road Pudong District Shanghai,China
Doi:10.1016/S0040-4039(00)96323-8
(1987)Doi:10.1016/0008-6215(85)85240-X
(1985)Doi:10.1016/0022-328X(85)80114-5
(1985)Doi:10.1021/ja00305a053
(1985)Doi:10.1021/jo01091a003
(1959)Doi:10.1021/ol990310q
(1999)
