First enantioselective addition of dialkylzinc to ketones promoted by titanium(IV) derivatives

Article abstract of DOI:10.1016/S0040-4039(97)10765-1

The reaction of dimethyl or diethylzinc with ketones in the presence of a stoichiometric amount of titanium tetraisopropoxide and a catalytic amount (20 mol %) of camphorsulfonamide derivatives as chiral ligands leads to the formation of the corresponding