7
2 Chaudhry et al.
Asian J. Chem.
TABLE-8
ANTIBACTERIAL SCREENING DATA OF LIGANDS AND COMPLEXES
[
DIAMETER OF INHIBITION ZONE (mm) AFTER 24 h INCUBATION]
Staphylococcus aureus Escherichia coli
Diameter of inhibition zone Activity (%) Diameter of inhibition zone
Compounds
Activity (%)
Concentration (ppm)
50
100
50
100
50
100
50
100
NBPS
25
27
28
32
28
34
38
40
45
35
38
36
40
37
41
45
49
60
55.5
60.0
62.0
71.0
62.0
75.5
84.0
89.0
100.0
58
63
60
67
62
68
75
82
100
28
30
34
36
35
37
40
46
52
39
42
45
48
46
50
49
54
64
54
58
65
69
67
71
77
88
100
61.0
66.0
70.0
75.0
72.0
78.0
76.5
84.0
100.0
NBPTS
[
[
[
[
[
[
Fe(NBPS) (CH COO) ]
2 3 2
Fe(NBPTS) (CH COO) ]
2
3
2
Ni(NBPS) (CH COO) ]
2
3
2
Ni(NBPTS) (CH COO) ]
2
3
2
Cu(NBPS) (CH COO) ]
2
3
2
Cu(NBPTS) (CH COO) ]
2
3
2
Streptomycin (standard)
1
1
3. V.S. Shekhawat, S. Varshney and A.K. Varshney, J. Indian Chem. Soc.,
4, 21 (2017).
4. S.A. Khan and N. Yusuf, Eur. J. Med. Chem., 44, 2270 (2009);
the greatest activity than all other complexes which may be
due to a toxic nature of copper metal. The increases in antibac-
terial activity of ligands after complexation may be attributed
to the formation of chelates in complexes [12,22].
9
https://doi.org/10.1016/j.ejmech.2008.06.008.
15. A.E. Graminha, C. Rodrigues,A.A. Batista, L.R. Teixeira, E.S. Fagundes
and H. Beraldo, Spectrochim. Acta A Mol. Biomol. Spectrosc., 69, 1073
Conclusion
(2008);
https://doi.org/10.1016/j.saa.2007.06.005.
The study reveals that the ligands are weakly coordinated
to the metal ions in XY plane than acetate ions along Z-axis
16. B.B. Mahapatra and S.K. Saraf, J. Indian Chem. Soc., 80, 696 (2003).
17. S.K. Sinha, D. Kumar, C.M. Chandra, B.N. Subash, S. Kumar and S.
Sharma, Int. J. Develop. Res., 7, 12295 (2017).
due to the presence of strongly electron withdrawing-NO
2
1
1
8. A. Sheela and N.L.H. Nair, J. Indian Chem. Soc., 89, 445 (2012).
9. R. Ranjan, N. Sinha, S. Kumar, C. M. Chandra and S. Sharma, IRA-
Int. J. Appl. Sci., 7, 34 (2017).
group in planar ligands. This makes tetragonally distorted
octahedral complexes with appreciable compression along Z-
axis which is well supported by the higher values of Dq(z) than
20. D. Das, A.K. Panda, P. Jana, S.B. Patjoshi and A. Mahapatra, J. Indian
Chem. Soc., 79, 48 (2002).
t
Dq(xy) and negative value of D in all the complexes. The anti-
2
1. M.K. Singh, A.D.R. Laskar and B. Pant, J. Indian Chem. Soc., 85, 485
2008).
bacterial screening of complexes reveals that all the complexes
have greater antibacterial activity than the free ligands confir-
ming the concept of enhancement of antibacterial activities of
a compound after complexatation.
(
2
2. A. Karim, R. Rani, R. Ranjan, U. Kumar, V. Kumar and S. Sharma,
Asian J. Chem., 29, 626 (2017);
https://doi.org/10.14233/ajchem.2017.20286.
2
3. S. Singh, P. Tripathi, O.P. Pandey and S.K. Sen Gupta, J. Indian Chem.
Soc., 90, 565 (2013).
REFERENCES
2
2
2
4. B.K. Rai and R. Kumari, Asian J. Chem., 23, 4625 (2011).
5. N.P. Singh, K.L. Anand and J. Singh, Asian J. Chem., 23, 4090 (2011).
6. R. Ranjan, R. Rani, S.S. Singh, A.K. Singh Jr. and S. Charma, Asian J.
Chem., 22, 7580 (2010).
1
.
I.B. Bersuker, Jahn-Teller Effect and Vibronic Interaction in Modern
Chemistry, Plenum Press, New York (1984).
2
3
.
.
D. Reinen and M. Atansov, Mag. Reson. Rev., 5, 167 (1971).
B.N. Figgis, Introduction to Ligand Field, Wiley Eastern Limited, New
Delhi, pp. 212-214 (1964).
2
2
7. A.K. Singh, S.P. Sinha, V. Kumar, S.S. Rai and S. Sharma, Asian J.
Chem., 23, 43 (2011).
8. R.L. De, R.K. De, I. Banerjee, N. Mandal, N. Ray, J. Mukharjee and E.
Keller, J. Indian Chem. Soc., 90, 27 (2013).
4
5
6
7
.
.
.
.
W. Zhang, J.L. Loebach, S.R. Wilson and E.N. Jacobsen, J. Am. Chem.
Soc., 112, 2801 (1990);
https://doi.org/10.1021/ja00163a052.
2
3
9. G.S. Sanya, P.K. Nath and R. Ganguly, J. Indian Chem. Soc., 79, 54 (2002).
0. M.A. Halcrow, Coord. Chem. Rev., 253, 2493 (2009);
https://doi.org/10.1016/j.ccr.2009.07.009.
F. Yamakura, K. Kobayashi, H. Ue and M. Konno, Eur. J. Biochem.,
227, 700 (1995);
https://doi.org/10.1111/j.1432-1033.1995.tb20191.x.
3
3
1. M. Matsuda, H. Isozaki and H. Tajima, Chem. Lett., 37, 374 (2008);
https://doi.org/10.1246/cl.2008.374.
A. Bencini, I. Ciofini and M.G. Uytterhoeven, Inorg. Chim. Acta, 274,
90 (1998);
2. A.B.P. Lever, Inorganic Electronic Spectroscopy, Elsevier, New York,
edn 2, p. 19 (1984).
https://doi.org/10.1016/S0020-1693(97)05985-9.
J.P. Renault, C. Verchère-Béaur, I. Morgenstern-Badarau, F. Yamakura
and M. Gerloch, Inorg. Chem., 39, 2666 (2000);
3
3
3
3. P. Bhatnagar and N.K. Bhatnagar, J. Indian Chem. Soc., 89, 1273 (2012).
4. N. Agrawal and A. Singh, J. Indian Chem. Soc., 90, 585 (2013).
5. M.A. Hitchman, Inorg. Chem., 11, 2387 (1972);
https://doi.org/10.1021/ic50116a019.
https://doi.org/10.1021/ic0000451.
8
9
.
.
S. Mossin, H. Weihe andA.-L. Barra, J. Am. Chem. Soc., 124, 8764 (2002);
https://doi.org/10.1021/ja012574p.
S.N. Pandeya, P. Yogeeswari and J.P. Stables, Eur. J. Med. Chem., 35,
3
3
6. E.I. Solomon and C.J. Ballhausen, Mol. Phys., 29, 279 (1975);
https://doi.org/10.1080/00268977500100191.
7. A.B.P. Lever, G. London and P.J. McCarthy, Can. J. Chem., 55, 3172
879 (2000);
https://doi.org/10.1016/S0223-5234(00)01169-7.
(1977);
https://doi.org/10.1139/v77-445.
1
1
1
0. M.R.P. Kurup, B.Varghese, M. Sithambaresan, S. Krishnan, S.R. Sheeja
and E. Suresh, Polyhedron, 30, 70 (2011);
https://doi.org/10.1016/j.poly.2010.09.030.
3
8. B.B. Mahapatra and N. Patel, J. Indian Chem. Soc., 86, 518 (2009).
39. D. Kumar, S. Sharma and R.C. Sharma, J. Indian Chem. Soc., 87, 1547
(2010).
1. V.L. Siji, M.R. Sudarsanakumar and S. Suma, Transition Met. Chem.,
36, 417 (2011);
https://doi.org/10.1007/s11243-011-9485-z.
40. M. Fujiwara, Y. Nakajima, T. Matsushita and T. Shumo, Polyhedron,
4, 1589 (1985);
2. S.R. Layana,V.L. Sigi, M.R. Sudarasana Kumar, S. Kumar, M.R.P. Kurup
and T.S. Sikha, J. Indian Chem. Soc., 93, 577 (2016).
https://doi.org/10.1016/S0277-5387(00)87233-2.
41. R.N. Patel, A.P. Patel and K.B. Pandaya, J. Indian Chem. Soc., 78, 6, (2001).