Efficient preparation of polyfunctional indoles via a zinc organometallic variation of the Fischer indole synthesis

Article abstract of DOI:10.1055/s-0030-1258348

Functionalized organozinc reagents readily react with various aryldiazonium salts furnishing regioselectively polyfunctional indoles after heating with microwave irradiation. This new organometallic variation of the Fischer indole synthesis tolerates a wide range of functional groups and can be readily scaled up. Georg Thieme Verlag Stuttgart · New York.