Journal of the Chilean Chemical Society p. 642 - 645 (2011)
Update date:2022-08-18
Topics:
Tian, Lingxing
Yang, Weijie
Chen, Xiaoqing
Xie, Yixi
The distribution behavior of ofloaxcin (OFLX) enantiomers in a two-phase system was examined using a new mixed complex chiral selector consisting of di(2-ethylhexyl) phosphoric acid (D2EHPA) and two tartaric acid derivatives with n-octanol as diluents. The influence of composition of mixed complex chiral selector, initial concentration of OFLX, pH of aqueous phase and temperature was investigated. A maximum enantioselectivity of 2.43 was obtained when the molar concentration ratio of L-(-)-DBTA to L-(-)-DTTA is 2:3 L-(-)-DTTA concentration 0.18 mol/L, L-(-)-DBTA concentration 0.12mol/L) and the pH of aqueous phase is 6.86 at 25°C, with DD and DL up to a relative high value of 10.2 and 4.20, respectively. The results indicated a useful way of searching new efficient chiral selectors and it was proved also helpful to optimize the extraction systems and realize the large-scale production of the pure isomer of racemic mixtures with extraction methods.
View MoreHe Bei Shun Er Chemical Co., LTD.
Contact:86-0311-86996932/86860168
Address:No 18,North street
ClickChem Technology Co., Limited
Contact:+86-0310-6519966/0531-52893837
Address:No.750 Shunhua Road, High-Tech Zone, Jinan city, Shandong China
NingBO Hong Xiang Biochem.Co.Ltd
website:http://www.hxbiochem.com
Contact:0574-66003444
Address:Ning Bo Bei Lun
Hunan Haili Chemical Industry Co.,Ltd.
Contact:+86-731-85521860
Address:No.251, 2nd Section, Furong Road, Changsha,Hunan,China
SuZhou Bichal Biological Technology CO.,LTD
Contact:+86-512-68051130
Address:NO.32 huoju road HI-TECH Industrial development zone SuZhou China
Doi:10.1021/ac00267a034
(1984)Doi:10.1359/jbmr.2001.16.3.441
(1899)Doi:10.1039/c2dt12182d
(2012)Doi:10.1002/anie.201509537
(2016)Doi:10.3390/molecules22010186
(2017)Doi:10.1016/S0022-328X(00)86645-0
(1981)