Synthesis of mono- and dimannoside phosphoramidite derivatives for solid-phase conjugation to oligonucleotides

Article abstract of DOI:10.1016/0040-4039(95)01512-G

Mannose and dimannose derivatives have been prepared with an anomerically-linked hydrophobic spacer, and converted to phoshoramidite derivatives suitable for conjugation to oligoribodeoxynucleotides on a DNA/RNA synthesizer. Synthesis of a monomannoside-linked 15-mer oligoribodeoxynucleotide is reported.