Organic Letters
Letter
importance of N−C bond activation manifolds,6 we expect that
the site-selective N,N-di-Boc activation/metal insertion strategy
will find broad applications in organic synthesis. Studies on
general activation of amide bonds are underway.
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ASSOCIATED CONTENT
* Supporting Information
■
S
The Supporting Information is available free of charge on the
Experimental procedures and characterization data
AUTHOR INFORMATION
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Corresponding Author
ORCID
Notes
N.; Gooßen, K. Angew. Chem., Int. Ed. 2008, 47, 3100. (d) Brennfuhrer,
̈
A.; Neumann, H.; Beller, M. Angew. Chem., Int. Ed. 2009, 48, 4114.
(19) Dineen, T. A.; Zajac, M. A.; Myers, A. G. J. Am. Chem. Soc. 2006,
128, 16406.
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
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(20) Barker, T. J.; Jarvo, E. R. J. Am. Chem. Soc. 2009, 131, 15598.
(21) Reviews on Negishi cross-coupling: (a) Haas, D.; Hammann, J.
M.; Greiner, R.; Knochel, P. ACS Catal. 2016, 6, 1540. (b) Benischke,
A. D.; Ellwart, M.; Becker, M. R.; Knochel, P. Synthesis 2016, 48, 1101.
(c) Handbook of Functionalized Organometallics; Knochel, P., Ed.;
Financial support was provided by Rutgers University. The 500
MHz spectrometer used in this study was supported by an
NSF-MRI grant (CHE-1229030).
Wiley: Weinheim, 2005. (d) Klatt, T.; Markiewicz, J. T.; Samann, C.;
̈
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