Investigational New Drugs p. 2035 - 2045 (2012)
Update date:2022-08-28
Topics:
Sutherland, Hamish S.
Hwang, In Young
Marshall, Elaine S.
Lindsay, Brent S.
Denny, William A.
Gilchrist, Catherine
Joseph, Wayne R.
Greenhalgh, Debra
Richardson, Emma
Kestell, Philip
Ding, Angela
Baguley, Bruce C.
Summary: Purpose The human tumour suppressor protein p53 is mutated in nearly half of human tumours and most mutant proteins have single amino acid changes. Several drugs including the quinazoline derivative 1 (CP-31398) have been reported to restore p53
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