BROMO- AND IODODEMERCURATION OF 8-TRIFLUOROACETOXYMERCURI DERIVATIVES OF THEOPHYLLINE AND THEOBROMINE

Article abstract of DOI:10.1007/BF00516220

Direct C-mercuration in the 8 position of N-acyl derivatives of theophylline and theobromine with mercury(II) trifluoroacetate in a mixture of anhydrous trifluoroacetic acid and trifluoroacetic anhydride is described. 8-Bromo and, respectively, 8-iodo derivatives of both dimethylxanthines were obtained in high yields from 8-trifluoroacetoxymercuri derivatives by the action of an aqueous solution of potassium tribromide or a solution of iodine in acetonitrile.