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363-24-6

Basic Information
CAS No.: 363-24-6
Name: Prostaglandin E2
Article Data: 32
Molecular Structure:
Molecular Structure of 363-24-6 (Prostaglandin E2)
Formula: C20H32O5
Molecular Weight: 352.471
Synonyms: 5-Heptenoicacid, 7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]- (8CI);(-)-Prostaglandin E2;(15S)-Prostaglandin E2;11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (5Z,11a,13E,15S);11a,15a-Dihydroxy-9-oxo-5-cis,13-trans-prostadienoic acid;Cervidil;Cerviprime;Dinoprostone;Enzaprost E;Minprositin E2;NSC 196514;PGE2;Primiprost;Prostaglandin E2;Prostenon;Prostenone;Prostin (prostaglandin);U 12062;Vivelle-Dot;l-Prostaglandin E2;
EINECS: 206-656-6
Density: 1.148 g/cm3
Melting Point: 66-68 °C
Boiling Point: 530.1 °C at 760 mmHg
Flash Point: 288.5 °C
Solubility: ethanol: 1 mg/mL
Appearance: white to pale yellowish-cream powder
Hazard Symbols: ToxicT
Risk Codes: 60-22
Safety: 53-22-26-36/37/39
PSA: 94.83000
LogP: 3.25110
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Chemistry

Molecular Formula:C20H32O5
Molecular Weight:352.52
EINECS:206-656-6
Density:1.148g/cm3
Melting Point:66-68°C
Boiling Point:530.1°Cat760mmHg
Flash Point:288.5°C
Solubility:insoluble
Properties:Crystals

Dinoprostone's Synonyms: Prostaglandin E2;9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID;7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]-5-heptenoic acid;(5Z,11A,13E,15S)-11,15-DIHYDROXY-9-OXO-PROSTA-5,13-DIEN-1OIC ACID;[5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIEN-1-OIC ACID;[5Z,11ALPHA,13E,15S]-11,15-DIHYDROXY-9-OXOPROSTA-5,13-DIENOIC ACID;PROSTAGLANDIN;PROSTAGLANDIN E2

Uses

Induction of labor

Toxicity Data With Reference

1.    

oms-mus:oth 100 nmol/L

    JIDEAE    Journal of Investigative Dermatology. 66 (1976),313.
2.    

spm-mus-ipr 3 mg/kg

    INJFA3    International Journal of Fertility. 21 (1976),82.
3.    

dns-gpg:lng 1 mg/L

    PSEBAA    Proceedings of the Society for Experimental Biology and Medicine. 171 (1982),109.
4.    

orl-rat LD50:500 mg/kg

    OYYAA2    Oyo Yakuri. Pharmacometrics. 8 (1974),787.
5.    

scu-rat LD50:31,600 µg/kg

    OYYAA2    Oyo Yakuri. Pharmacometrics. 8 (1974),787.
6.    

ivn-rat LD50:59,500 µg/kg

    OYYAA2    Oyo Yakuri. Pharmacometrics. 8 (1974),787.
7.    

orl-mus LD50:750 mg/kg

    OYYAA2    Oyo Yakuri. Pharmacometrics. 8 (1974),787.
8.    

scu-mus LD50:19,700 µg/kg

    OYYAA2    Oyo Yakuri. Pharmacometrics. 8 (1974),787.
9.    

ivn-mus LD50:23,200 µg/kg

    OYYAA2    Oyo Yakuri. Pharmacometrics. 8 (1974),787.
10.    

ipr-ham LD50:1 mg/kg

    PLMEDD    Prostaglandins, Leukotrienes and Medicine. 17 (1985),309.

Safety Profile

Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Human reproductive effects by intravenous, intraplacental, and intravaginal routes: changes in the uterus, cervix and vagina; termination of pregnancy; and changes in fertility. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Dinoprostone's Safety Information
Hazard Codes  T
Risk Statements  60-22
Safety Statements  53-22-26-36/37/39
WGK Germany  3
RTECS  UK8000000
F  8-10
 

Specification

Dinoprostone's Handling and Storage 
【Storage】Keep container closed when not in use. Deep freeze (below -20 C). Store protected from light. Store with dessicant.
【Handling】Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Store protected from light. Use only in a chemical fume hood.