Tetrahedron Letters p. 1883 - 1884 (1996)
Update date:2022-08-17
Topics:
Dekhane, Mouloud
Douglas, Kenneth T.
Gilbert, Peter
The naturally occurring 3-oxohexanoyl-L-homoserinelactone (1a), a bacterial autoinducer has been prepared in 47% overall yield by condensing stable 3-oxohexanoic acid (2), prepared by hydrolysis from the corresponding ester (3), with L-homoserinelactone using hydroxybenzotriazole (HOBT) and dicyclohexylcarbodiimide (DCC) in non-aqueous media.
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