67-03-8 Usage
Description
Different sources of media describe the Description of 67-03-8 differently. You can refer to the following data:
1. Thiamine Hydrochloride is the hydrochloride salt form of thiamine (vitamin B1), a vitamin essential for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. Vitamin B1 helps prevent various health problems including heart damage.
Thiamine hydrochloride is used to prevent and treat thiamine deficiency states, which may occur as a result of inadequate nutrition or intestinal malabsorption. It is also used for the treatment of Wernicke-Korsakoff syndrome, beriberi and thiamine deficiency related to chronic alcoholism. Thiamine hydrochloride is used as a food additive to add brothy/meaty flavor to gravies or soups. It is used also as a food supplement and flavoring ingredient with a bitter taste.
2. In 1912, Cashmir Funk isolated thiamine from rice husks and
coined the term ‘vitamine’ because it was required for life
(‘vita’) and because thiamine contained nitrogen (‘amine’).
Thiamine, formerly known as B1, is water soluble. Thiamine is
a vital cofactor for enzymes and coenzymes of glycolysis, the
Kreb’s cycle, the pentose phosphate pathway. Thiamine is also
involved in the biosynthesis of the neurotransmitters acetylcholine
and gamma-aminobutyric acid and in nerve
propagation.
References
[1] https://www.drugs.com
[2] Shmuel Yannai (2012) Dictionary of Food Compounds with CD-ROM, Second Edition
[3] https://www.medicines.org.uk
Chemical Properties
Vitamin B1 has an odor slightly reminiscent of thiazole and a bitter taste. When exposed to air, the vitamin rapidly
absorbs about 4% of water.
Occurrence
Rice husks are reportedly the principal source of vitamin B1; in variable amounts it is a constituent of yeast,
milk, green leaves, roots and tubers; it is also present in high concentration in seeds, and in lesser amount in different animal organs
and muscles.
Uses
Different sources of media describe the Uses of 67-03-8 differently. You can refer to the following data:
1. Thiamine is the water-soluble vitamin b1, required for normal digestion and functioning of nerve tissues and in the prevention of beriberi. It also acts as a coenzyme in the metabolism of carbohydrates. During processing, the higher and longer the heating period, the greater the loss. The loss is reduced in the presence of acid. Thiamine hydrochloride and thiamine mononitrate are two available forms. The mononitrate form is less hygroscopic and more stable than the hydrochloride form, making it suitable for use in beverage powders. It is used in enriched flour and is found as thiamine mononitrite in frozen egg substitute and crackers.
2. Thiamine is a essential nutrient required for carbohydrate metabolism; also involved in nerve function. Biosynthesized by microorganisms and plants. Dietary sources include whole grains, meat products
, vegetables, milk, legumes and fruit. Also present in rice husks and yeast. Converted in vivo to Thiamine diphosphate, a coenzyme in the decarboxylation of α-keto acids. Chronic deficiency may lead t
o neurological impairment, bariberi, Wernicke-Korsakoff syndrome.
3. A cofactor required for oxidation of carbohydrates and for the synthesis of ribose.
Definition
ChEBI: A hydrochloride obtained by combining thiamine chloride with one molar equivalent of hydrochloric acid.
Preparation
By linking the preformed thiazole and pyrimidine ring system.
General Description
Thiamine is a water-soluble vitamin of the B complex whose phosphate derivatives are involved in many cellular processes required for overall human health. Thiamine deficiency, often the result of impaired nutritional status associated with chronic diseases from alcoholism to HIV-AIDS, is monitored in patient whole blood samples by HPLC.
Health Hazard
Diseases and disorders resulting from a deficiency of thiamine include beriberi, opisthotonos (in birds), polyneuritis, hyperesthesia, bradycardia, and edema. Rather than a specific disease, beriberi may be described as a clinical state resulting from a thiamine deficiency. In body cells, thiamine pyrophosphate is required for removing carbon dioxide from various substances, including pyruvic acid.
Biochem/physiol Actions
Thiamine is an essential coenzyme in carbohydrate metabolism. Deficiency of thiamine causes beriberi, a neurological and cardiovascular disease. Thiamine is administered in case of deficiency, either due to reduced intake or synthesis. Congenital defect in the thiamine transporter gene SLC19A2 causes thiamine-responsive megaloblastic anemia syndrome (TRMA). Thiamine mimics acetylcholine in brain and possible exerts a role in Alzheimer′s disease. Thiamine deficiency in ruminants causes polioencephalomalacia.
Safety Profile
Poison by intravenous
and intraperitoneal routes. Mildly toxic by
ingestion. The vitamin is destroyed by
alkalies and alkaline drugs such as
phenobarbital sodium and by oxidzing and
reducing agents. When heated to
decomposition it emits very toxic fumes of
HCl, Cl-, SOx, and NOx.
Environmental Fate
Thiamine and its common phosphate analogs are readily
soluble in water and ubiquitously utilized in nature.
Purification Methods
The hydrochloride crystallises from 95% EtOH (solubility is ca 1%). The monohydrate is dehydrated at 100o in vacuo over H2SO4, but is hygroscopic and picks up one molecule of H2O readily. It can be sterilised at 100o if the pH of the solution is below 5.5. The nitrate has m 196-200o(dec) and is more stable than the hydrochloride. The picrolonate crystallises from H2O and is dimorphic, m 164-165o and 228-229o(dec). [Todd & Bergel J Chem Soc 364, 367 1937, J Am Chem Soc 58 1063, 1504 1936, 59 526 1937, Beilstein 27 IV 1766.]
Check Digit Verification of cas no
The CAS Registry Mumber 67-03-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 7 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 67-03:
(4*6)+(3*7)+(2*0)+(1*3)=48
48 % 10 = 8
So 67-03-8 is a valid CAS Registry Number.
InChI:InChI=1/2C12H17N4OS.4ClH/c2*1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;;;/h2*5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);4*1H/q2*+1;;;;/p-4
67-03-8Relevant articles and documents
Possible impurities in 2-methyl-4-amino-5-chloromethylpyrimidine and the resulting quality of vitamin B1
Litvak
, p. 101 - 103 (1999)
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Synthetic process for chlorinated thiazole onium hydrochloride
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Paragraph 0027; 0028; 0029; 0030; 0031; 0032, (2017/06/06)
The invention provides a synthetic process for chlorinated thiazole onium hydrochloride. The synthetic process includes the following steps that sulfo-thiamine hydrochloride and hydrochloric acid are added into a three-neck flask, and then the flask is put into a freezing tank and cooled to minus 10 DEG C; hydrogen peroxide is added slowly, and the temperature is controlled to be minus 10 DEG C; after addition of hydrogen peroxide is finished, reaction is carried out for 20 h on the heat preservation condition; after heat preservation is finished, chlorinated thiazole onium hydrochloride is filtered, separated out, cleaned with methyl alcohol and dried to obtain the finished chlorinated thiazole onium hydrochloride product. The synthetic process has the advantages of shortening the process route, saving reaction time, reducing production cost, reducing discharge of salt-bearing wastewater and the like.
Controlled release pharmaceutical preparation
-
, (2008/06/13)
A controlled release pharmaceutical preparation comprising a core containing a medicinal compound and a coating layer containing a water-repellent salt and a water-insoluble and slightly water-permeable acrylic polymer having trimethylammoniumethyl group. Said preparation releases a medicinal compound in a sigmoid type dissolution pattern irrespective of the PH of a dissolution medium.
