Tetrahedron Asymmetry p. 1687 - 1690 (2000)
Update date:2022-08-10
Topics:
Brown, Stuart A.
Parker, Marie-Claire
Turner, Nicholas J.
Candida antarctica lipase B (Novozyme) is an effective catalyst for the dynamic kinetic resolution of racemic 2-benzyl-4-substituted-5(4H)- oxazolones, in the presence of an alcohol, yielding optically active N- benzoyl amino acid esters. The reaction has been optimised with respect to the solvent and the effect of a catalytic amount of organic base is investigated. (C) 2000 Elsevier Science Ltd.
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