A mechanistic and structural analysis of the basis for high enantioselectivity in the oxazaborolidine-catalyzed reduction of trihalomethyl ketones by catecholborane

Article abstract of DOI:10.1016/S0040-4039(00)60848-1

The rates and enantioselectivities of the reduction of a series of trihalomethyl ketones under catalysis by oxazaborolidine 2 can be explained in terms of structural and mechanistic analyses which are detailed herein and which have predictive value.