Chemical and Pharmaceutical Bulletin p. 499 - 504 (1997)
Update date:2022-08-17
Topics:
Nakamura, Tomonori
Okuyama, Emi
Tsukada, Atsushi
Yamazaki, Mikio
Satake, Motoyoshi
Nishibe, Sansei
Deyama, Takeshi
Moriya, Akira
Maruno, Masao
Nishimura, Hiroaki
Acteoside (verbascoside) was isolated as an analgesic principle from Cedron (leaves and stem of Lippia triphylla (L'HER) O. KUNTZE; Verbenaceae), a Peruvian medicinal plant, by activity-guided separation. The compound exhibited analgesia on acetic acid-induced writhing and on tail pressure pain in mice by the oral administration of 300mg/kg and 100mg/kg, respectively. Acteoside also caused weak sedation by its effect on the prolongation of pentobarbital-induced anesthesia and on the depression of locomotion enhanced by methamphetamine. An intravenous injection of acteoside reduced the effective dose to 2mg/kg by the writhing method. Thirteen related compounds were tested for the activity by intravenous and oral administration to obtain information on the active structure.
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