Tetrahedron Letters p. 805 - 808 (1987)
Update date:2022-08-22
Topics:
Makita, Atushi
Nihira, Takuya
Yamada, Yasuhiro
A new method for the preparation of macrocyclic lactones from ω-hydroxyacid methyl esters is described.The approach utilizes intramolecular transesterification catalyzed by lipase in organic solvents.The procedure is also applicable to the synthesis of asymmetric lactones.
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