Angewandte Chemie International Edition
10.1002/anie.201814088
COMMUNICATION
In conclusion, flash chemistry based on flow microreactor
systems allowed alkyllithiums bearing electrophilic functional
groups to be successfully generated and used for subsequent
reactions. The series of reactions with high reactivity was
achieved by extremely accurate control over residence time in a
controlled and selective manner. The present findings open a new
world of organolithium chemistry.
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This work was partially supported by the Grant-in-Aid for Scientific
Research on Innovative Areas 2707 Middle molecular strategy
from MEXT (no. 15H05849), Scientific Research (B) (no.
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6288049), Scientific Research (S) (no. 26220804), Scientific
Research (S) (no. 25220913), Scientific Research (C) (no.
7865428), AMED (no. 18ak0101090h), the Japan Science and
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Technology Agency’s (JST) A-step program (no. 18067420),
CREST, and the Ogasawara Foundation for the Promotion of
Science & Engineering
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Keywords: microreactors・alkyllithiums・electrophilic-functional
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