Tetrahedron Letters p. 4253 - 4256 (1986)
Update date:2022-08-11
Topics:
Agarwal, S. K.
Boyd, D. R.
Porter, H. P.
Jennings, W. B.
Grossman, S. J.
Jerina, D. M.
Arene oxides and trans-dihydrodiols at the 5,6- and 7,8-positions of quinoline have been synthesized.High stability of both arene oxides allowed identification of the 5,6-oxide as a liver microsomal metabolite of quinoline.Both arene oxides are converted to trans-dihydrodiols by microsomal epoxide hydrolase.
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