SYNTHESIS OF AMINO ACID ESTERS BY PAPAIN

Article abstract of DOI:10.1016/S0040-4020(01)81493-9

A wide range of N-Boc-amino acid esters were synthesized from N-Boc-amino acids and alcohol using papain as catalyst.Suitable biphasic reaction mixtures were found for most amino acids to achieve high yield of ester synthesis.With N-Boc-L-aspartic and glutamic acids only the α carbonyl group esterified, without racemisation.