Synthesis of Optically Active 4-Hydroxyalkanenitriles via an Enzymatic Reaction

DOI: 10.1246/bcsj.66.2949

Source and publish data:

Bulletin of the Chemical Society of Japan p. 2949 - 2953 (1993)

Update date:2022-08-16

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Authors:

Takagi, Yumiko

Itoh, Toshiyuki

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Article abstract of DOI:10.1246/bcsj.66.2949

Lipase-catalyzed enantioselective hydrolysis of esters of 4-hydroxyalkanenitriles was demonstrated for the first time.Efficient optical resolution was achieved when (+/-)-3-cyano-1-phenylpropyl 2-(phenylthio)acetate was hydrolyzed by lipase PS (Pseudomona

Full text of DOI:10.1246/bcsj.66.2949

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