
Tetrahedron Letters p. 2729 - 2732 (1995)
Update date:2022-08-11
Topics:
Zhang, Wei
Collins, Michael R.
Mahmood, Khalid
Dowd, Paul
Free radical expansion of fused-cyclobutanones gives bicyclic ketones expanded by three and four carbons, with the carbonyl group β to the ring junction.Four-carbon ring expansion shows stereoselectivity favoring the trans-fused product 6-trans.The radical precursor cyclobutanones are readily prepared by intramolecular <2+2> cycloaddition of ketenes or keteniminium salts to olefins.
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